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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

Fig. 5

HMGA2 was found as a downstream target of miR-205-5p. A The binding sites of miR-205-5p in HMGA2 3′UTR was predicted by starbase v2.0. B, C The binding between miR-205-5p and HMGA2 was explored using dual-luciferase reporter assay (B) and RIP assay (C). D HMGA2 mRNA expression was assayed by qRT-PCR in normal and DN samples. E The linear relation between the expression of miR-205-5p and HMGA2 was analyzed by Pearson’s correlation coefficient. F The protein detection of HMGA2 was performed by western blot in control and HG groups. G Western blot was used to assess the effect of miR-205-5p on the HMGA2 protein level. ***P < 0.001, ****P < 0.0001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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