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Table 3 Comparison of characteristics of patients in long-term (LT) group at baseline and after 6 months of withdrawal

From: Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study

 

Baseline

After 6 months

p

Body weight (kg)

87 (75–103)

89.4 ± 15.8

87 (73–105)

91 ± 17.1

0.058

BMI (kg/m2)

32.5 (27.7–38.8)

32.8 ± 5.7

32.5 (28.1–37.8)

33.4 ± 6.2

0.056

Waist circumference (cm)

98 (92–110)

102 (90–113)

0.501

Systolic blood pressure (mmHg)

118 (113–130)

118 (111–122)

0.211

Diastolic blood pressure (mmHg)

87 (81–92)

85 (74–86)

0.010

No. of menstrual bleeding in last 6 month

6 (6–6)

6 (4–6)

0.027

TFEQ-R18: cognitive restraint (%)

66.7 (61.1–83.3)

47.2 (37.5–61.1)

0.003

TFEQ-R18: emotional eating (%)

33.3 (11.1–55.6)

33.3 (11.1–58.3)

0.522

TFEQ-R18: uncontrolled eating (%)

22.2 (7.4–44.4)

29.6 (18.5–42.6)

0.469

Total cholesterol (nmol/L)

4.9 (4.3–5.3)

4.9 (4.3–5.2)

0.733

HDL (mmol/L)

1.5 (1.2–1.8)

1.6 (1.2–1.7)

0.658

LDL (mmol/L)

2.6 (2.3–3.2)

2.5 (2.1–3.1)

0.454

TG (mmol/L)

1.3 (0.8–2.1)

1.3 (0.8–1.9)

0.874

FSH (IU/L)

5.4 (3.9–7)

5.4 (3.2–6.3)

0.977

LH (IU/L)

7.3 (2.7–11.1)

6.1 (2.8–8.4)

0.910

SHBG (nmol/L)

42.2 (28.5–76.4)

39.7 (32.5–56.5)

0.925

Total testosterone (nmol/L)

0.95 (0.69–1.1)

0.73 (0.69–1.36)

0.530

FAI score (%)

2 (1–4)

2 (2–3)

0.752

Free testosterone (pmol/L)

6.7 (4.4–8.4)

6.9 (4.8–7.5)

0.820

Androstenedione (nmol/L)

6.4 (4.6–7.6)

7.8 (4.8–9.6)

0.053

Glucose OGTT 0 (mmol/L)

5.1 (4.9–5.5)

5.3 (4.7–5.6)

0.800

Glucose OGTT 120 (mmol/L)

5.9 (4.6–6.9)

5.4 (4–6.5)

0.233

Insulin OGTT 0 (mU/L)

0.7 (0.5–1)

0.6 (0.4–0.8)

0.319

Insulin OGTT 120 (mU/L)

40.7 (13.2–80.9) [

45.7 (43.1–81.3)

0.826

HOMA-IR score

1.4 (0.6–2.1)

1.6 (0.5–2.7)

0.875

  1. Legend of abbreviations used in every table: BMI: body mass index; TFEQ-R18: three factor eating questionnaire; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglyceride; FSH: follicle stimulating hormone; LH: luteinizing hormone; SHBG: sex hormone-binding globulin
  2. Values of androgens in the healthy matched population: total testosterone 0.3–3.5 nmol/L; free testosterone 0.14–7.0 pmol/L; SHBG: 18–114 nmol/L; androstenedione: 0.7–10.8 nmol/L; FAI score: free androgen index 0.3–4.4%; HOMA-IR: homeostasis model assessment of insulin resistance