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Table 1 Comparisons of patient characteristics between the TBR ≥ 1% group and TBR < 1% group

From: The association between hypoglycemia and glycemic variability in elderly patients with type 2 diabetes: a prospective observational study

 

Total patients

TBR ≥ 1% group

TBR < 1% group

P value

n

179

57

122

 

Age (years)

73.0 (68.0, 78.0)

74.0 (70.0, 79.0)

72.0 (68.0, 78.0)

0.0833

Females (%)

71 (39.7)

23 (40.4)

48 (39.3)

1.0000

BMI (kg/m2)

24.2 (22.0, 26.8)

23.6 (21.2, 25.1)

24.5 (22.1, 27.1)

0.0534

Diabetes duration (years)

16.0 (10.0, 24.0)

19.0 (12.5, 25.0)

15.0 (9.0, 24.0)

0.2620

Diabetic retinopathy

63 (35.4)

22 (38.6)

41 (33.9)

0.6148

Diabetic neuropathy

79 (49.4)

28 (51.9)

51 (48.1)

0.7386

Diabetic nephropathy

93 (52.0)

29 (50.9)

64 (52.7)

0.8735

Hypertension

134 (75.3)

43 (76.8)

91 (74.6)

0.8524

Dyslipidemia

124 (69.7)

41 (73.2)

83 (68.0)

0.5988

Hyperuricemia

32 (18.0)

10 (17.9)

22 (18.0)

1.0000

Diabetes treatment

 Any insulin (%)

74 (41.3)

36 (63.2)

38 (31.2)

< 0.0001

 Sulfonylureas (%)

52 (29.1)

16 (28.1)

36 (29.5)

1.0000

 Glinides (%)

27 (15.1)

11 (19.3)

16 (13.1)

0.3697

 Metformin (%)

96 (53.6)

34 (59.7)

62 (50.8)

0.3346

 Thiazolidine (%)

13 (7.3)

4 (7.0)

9 (7.4)

1.0000

 α-Glucosidase inhibitors (%)

33 (18.4)

9 (15.8)

24 (19.7)

0.6796

 DPP-4 inhibitors (%)

135 (75.4)

42 (73.7)

93 (76.2)

0.7131

 GLP-1 receptor agonists (%)

18 (10.1)

6 (10.5)

12 (9.8)

1.0000

 SGLT2 inhibitors (%)

30 (16.8)

6 (10.5)

24 (19.7)

0.1395

 Acute coronary syndrome (%)

26 (14.5)

11 (19.3)

15 (12.3)

0.2560

 History of stroke or TIA (%)

25 (14.0)

13 (22.8)

12 (9.8)

0.0350

 FPG (mg/dL)

134.0 (116.0, 156.0)

119.0 (105.0, 135.5)

142 (123.0, 165.3)

< 0.0001

 HbA1c (%)

7.1 (6.7, 7.7)

7.0 (6.6, 7.6)

7.2 (6.8, 7.8)

0.0387

 HbA1c (mmol/mol)

54.1 (49.7, 60.7)

53.0 (48.6, 59.6)

55.2 (50.8, 61.7)

0.0387

 CPI (ng/mL per mg/dL)

1.1 (0.7, 1.7)

1.0 (0.5, 1.5)

1.2 (0.9, 1.8)

0.0228

 eGFR (mL/min/1.73 m2)

62.8 (48.4, 70.0)

58.0 (45.9, 68.3)

63.2 (50.6, 70.7)

0.1780

  1. Values are expressed as median (interquartile range) or number (%) of patients in each category. The Mann–Whitney U-test or Fisher’s exact test was used for comparisons of the parameters between the TBR ≥ 1% group and TBR < 1% group
  2. BMI body mass index, DPP‐4 dipeptidyl peptidase‐4, GLP‐1 glucagon‐like peptide‐1, SGLT2 sodium–glucose cotransporter 2, TIA transient ischemic attack, FPG fasting plasma glucose, CPI C-peptide index, eGFR estimated glomerular filtration rate, TBR time below target glucose range
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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