From: A review of flash glucose monitoring in type 2 diabetes
Randomized controlled trial | Outcome (FGMS vs. SMBG) [N = 149 vs. N = 75] | P value | |
---|---|---|---|
Overall population (6 months) | Mean change from baseline in HbA1c: | − 0.29 ± 0.07 vs. − 0.31 ± 0.09% | P = 0.8222 |
Subgroup analyses (6 months) | |||
Age | |||
< 65 years | Mean change from baseline in HbA1c: | − 0.53 ± 0.09 vs. − 0.20 ± 0.12% | P = 0.0301 |
≥ 65 years | − 0.05 ± 0.10 vs. − 0.49 ± 0.13% | P = 0.0081 | |
Time spent in hypoglycemia [h/day]: mean change from baseline | |||
Glucose < 70 mg/dL | Between-group difference: | − 43% [mean ± SE − 0.47 ± 0.13] | P = 0.0006 |
Glucose < 55 mg/dL | − 53% [− 0.22 ± 0.07] | P = 0.0014 | |
Glucose < 45 mg/dL | − 64% [− 0.14 ± 0.04] | P = 0.0013 | |
Frequency of hypoglycemic events [per day]: mean change from baseline | |||
Glucose < 70 mg/dL | Between-group difference: | − 28% [mean ± SE − 0.16 ± 0.07] | P = 0.0164 |
Glucose < 55 mg/dL | − 44% [− 0.12 ± 0.04] | P = 0.0017 | |
Glucose < 45 mg/dL | − 49% [− 0.06 ± 0.02] | P = 0.0098 | |
AUC [h/day × mg/dL] | |||
Glucose < 70 mg/dL | Between-group difference: | − 51% [mean ± SE − 7.80 ± 2.20] | P = 0.0005 |
Glucose < 55 mg/dL | − 60% [− 2.51 ± 0.76] | P = 0.0012 | |
Glucose < 45 mg/dL | − 67% [− 0.70 ± 0.22] | P = 0.0015 |
Extension phase | Outcome (FGMS vs. baseline) [N = 139] | ||
---|---|---|---|
Subgroup analyses (12 months) | |||
Time spent in hypoglycemia [h/day] | |||
Glucose < 70 mg/dL | Mean change from baseline (start of treatment phase): | − 50% [mean ± SD − 0.70 ± 1.85] | P = 0.0002 |
Glucose < 55 mg/dL | − 62% [− 0.40 ± 1.09] | P = 0.0002 | |
Glucose < 45 mg/dL | − 67% [− 0.23 ± 0.73] | P = 0.0013 | |
Frequency of hypoglycemic events [per day] | |||
Glucose < 70 mg/dL | Mean change from baseline (start of treatment phase): | − 41% [mean ± SD − 0.27 ± 0.67] | P < 0.0001 |
Glucose < 55 mg/dL | − 56% [− 0.20 ± 0.49] | P < 0.0001 | |
Glucose < 45 mg/dL | − 62% [− 0.13 ± 0.35] | P = 0.0002 | |
AUC [h/day × mg/dL] | |||
Glucose < 70 mg/dL | Mean change from baseline (start of treatment phase): | − 58% (mean ± SD − 12.73 ± 34.53] | P = 0.0002 |
Glucose < 55 mg/dL | − 65% [− 4.28 ± 12.76] | P = 0.0007 | |
Glucose < 45 mg/dL | − 69% [− 1.12 ± 3.67] | P = 0.0021 |