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Table 4 Participants characteristics according to hepatic image results combined (US + TE)

From: Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

 

Altered hepatic image

Normal hepatic image

p value

N

30

65

 

Clinical variables

Age, years

39 ± 12

39 ± 13

0.995

Female, n (%)

18 (60.0)

37 (56.9)

0.778

Non-Caucasian, n (%)

15 (50.0)

33 (50.8)

0.994

Years of formal education

12 ± 4

12 ± 3

0.498

Diabetes duration, years

21 ± 10

20 ± 9

0.738

BMI, kg/m2

27.9 ± 3.9

24.2 ± 3.6

 < 0.001

Waist circumference, cm

92.1 ± 11.2

83.1 ± 10.8

 < 0.001

Hip circumference, cm

102.4 ± 7.9

97.9 ± 7.1

0.006

Waist-to-hip ratio

0.90 ± 0.08

0.85 ± 0.08

0.003

Systolic blood pressure, mmHg

131 ± 16

125 ± 16

0.092

Diastolic blood pressure, mmHg

79 ± 11

76 ± 10

0.297

Metabolic syndrome, n (%)

21 (67.7)

21 (30.0)

0.001

Insulin dose, U/kg

0.78 ± 0.28

0.76 ± 0.32

0.741

Anti-hypertensive use, n (%)

15 (50.0)

24 (36.9)

0.228

Metformin use, n (%)

5 (16.7)

6 (9.2)

0.292

Statin use, n (%)

16 (53.3)

28 (43.1)

0.351

Acetylsalicylic acid use, n (%)

7 (23.3)

11 (16.9)

0.459

Currently smoking, n (%)

3 (10.0)

3 (4.6)

0.316

Laboratory measurements

HbA1c, %

mmol/mol

8.9 [3.0]

74 [32]

8.5 [2.2]

69 [21]

0.717

Fasting plasma glucose, mg/dl

130 [175]

116 [137]

0.880

Total cholesterol, mg/dl

168.5 [62.8]

161.0 [66.0]

0.771

HDL cholesterol, mg/dl

45.8 [26.0]

48.6 [32.0]

0.880

LDL cholesterol, mg/dl

95.8 [51.7]

92.6 [39.6]

0.383

Triglycerides, mg/dl

103.0 [103.8]

72.0 [61.5]

0.040

eGFR, ml/min/1.73 m2

103 [32]

99 [28]

0.771

Albumin, mg/dl

3.9 ± 0.7

4.0 ± 0.6

0.268

ALT, U/l

10.0 [11.3]

8.0 [6.5]

0.260

AST, U/l

14.5 [11.5]

12.0 [6.0]

0.082

GGT, U/l

19.5 [17.3]

19.0 [17.5]

0.830

CPK, U/l

100.5 [142.3]

81.0 [85.5]

0.667

C-reactive protein, mg/dl

0.3 [0.7]

0.2 [0.4]

0.771

Uric acid, mg/dl

3.8 [1.5]

3.5 [2.0]

0.383

Fatty liver index

46 [52]

11 [21]

 < 0.001

TE measurements

CAP, dB/m

234 ± 51

174 ± 33

 < 0.001

LSM, kPa

5.6 [3.9]

4.8 [1.8]

0.276

  1. Altered image refers to steatosis on ultrasound and/or steatosis and/or fibrosis on transient elastography (TE). Data are represented as means ± standard deviation, median [interquartile range] or as numbers (percentages). BMI: body mass index; HbA1c: glycated hemoglobin; eGFR: estimated glomerular filtration rate; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transferase; CPK: creatine phosphokinase; CAP: controlled attenuation parameter; LSM: liver stiffness measurement