Altered hepatic image | Normal hepatic image | p value | |
---|---|---|---|
N | 30 | 65 | |
Clinical variables | |||
Age, years | 39 ± 12 | 39 ± 13 | 0.995 |
Female, n (%) | 18 (60.0) | 37 (56.9) | 0.778 |
Non-Caucasian, n (%) | 15 (50.0) | 33 (50.8) | 0.994 |
Years of formal education | 12 ± 4 | 12 ± 3 | 0.498 |
Diabetes duration, years | 21 ± 10 | 20 ± 9 | 0.738 |
BMI, kg/m2 | 27.9 ± 3.9 | 24.2 ± 3.6 | < 0.001 |
Waist circumference, cm | 92.1 ± 11.2 | 83.1 ± 10.8 | < 0.001 |
Hip circumference, cm | 102.4 ± 7.9 | 97.9 ± 7.1 | 0.006 |
Waist-to-hip ratio | 0.90 ± 0.08 | 0.85 ± 0.08 | 0.003 |
Systolic blood pressure, mmHg | 131 ± 16 | 125 ± 16 | 0.092 |
Diastolic blood pressure, mmHg | 79 ± 11 | 76 ± 10 | 0.297 |
Metabolic syndrome, n (%) | 21 (67.7) | 21 (30.0) | 0.001 |
Insulin dose, U/kg | 0.78 ± 0.28 | 0.76 ± 0.32 | 0.741 |
Anti-hypertensive use, n (%) | 15 (50.0) | 24 (36.9) | 0.228 |
Metformin use, n (%) | 5 (16.7) | 6 (9.2) | 0.292 |
Statin use, n (%) | 16 (53.3) | 28 (43.1) | 0.351 |
Acetylsalicylic acid use, n (%) | 7 (23.3) | 11 (16.9) | 0.459 |
Currently smoking, n (%) | 3 (10.0) | 3 (4.6) | 0.316 |
Laboratory measurements | |||
HbA1c, % mmol/mol | 8.9 [3.0] 74 [32] | 8.5 [2.2] 69 [21] | 0.717 |
Fasting plasma glucose, mg/dl | 130 [175] | 116 [137] | 0.880 |
Total cholesterol, mg/dl | 168.5 [62.8] | 161.0 [66.0] | 0.771 |
HDL cholesterol, mg/dl | 45.8 [26.0] | 48.6 [32.0] | 0.880 |
LDL cholesterol, mg/dl | 95.8 [51.7] | 92.6 [39.6] | 0.383 |
Triglycerides, mg/dl | 103.0 [103.8] | 72.0 [61.5] | 0.040 |
eGFR, ml/min/1.73 m2 | 103 [32] | 99 [28] | 0.771 |
Albumin, mg/dl | 3.9 ± 0.7 | 4.0 ± 0.6 | 0.268 |
ALT, U/l | 10.0 [11.3] | 8.0 [6.5] | 0.260 |
AST, U/l | 14.5 [11.5] | 12.0 [6.0] | 0.082 |
GGT, U/l | 19.5 [17.3] | 19.0 [17.5] | 0.830 |
CPK, U/l | 100.5 [142.3] | 81.0 [85.5] | 0.667 |
C-reactive protein, mg/dl | 0.3 [0.7] | 0.2 [0.4] | 0.771 |
Uric acid, mg/dl | 3.8 [1.5] | 3.5 [2.0] | 0.383 |
Fatty liver index | 46 [52] | 11 [21] | < 0.001 |
TE measurements | |||
CAP, dB/m | 234 ± 51 | 174 ± 33 | < 0.001 |
LSM, kPa | 5.6 [3.9] | 4.8 [1.8] | 0.276 |