Table 2 Time course of clinical parameters in a patient with NASH

BMI

22.3

22.4

22.3

22.1

22.1

22.2

22.3

22.4

22.4

22.3

22.3

AST (U/L)

69

48

45

48

61

54

47

28

23

20

21

ALT (U/L)

83

60

52

60

79

55

55

33

26

19

19

Plt (10(9)/L)

198

212

227

223

204

214

227

218

228

233

243

FIB-4

2.78

1.99

1.79

1.99

2.29

2.31

1.93

1.58

1.4

1.4

1.47

Mac2BPGi

1.12

0.93

0.99

1.01

1.14

1.03

1.09

0.83

0.72

0.68

0.58

Type4Collagen

209

191

211

186

179

174

165

(ng/ml)

hsCRP (mg/dl)

0.054

0.039

0.042

0.038

0.048

0.039

0.04

0.04

0.023

0.028

0.009

FBS (mg/dl)

158

148

149

163

178

160

156

128

134

114

124

HbA1c (%)

7.8

6.8

7.2

7.6

7.4

6.9

6.6

6.5

6.5

6.4

6.5

IRI (IU/ml)

6.7

6.6

5.7

6.2

5

6.1

5.9

4.4

4.6

4.5

3.8

HOMA-IR

2.61

2.41

2.1

2.5

2.19

2.41

2.27

1.39

1.52

1.26

1.16

TG (mg/dl)

116

155

133

116

132

150

153

73

75

126

89

Total-C (mg/dl)

175

173

193

175

179

151

157

152

141

171

158

HDL-C (mg/dl)

37

34

43

37

41

36

358

41

41

45

43

LDL-C (mg/dl)

115

108

120

115

110

85

88

96

85

101

98

rosuvastatin

(mg/day)

2.5

2.5

2.5

2.5

2.5

2.5

2.5

2.5

2.5

2.5

2.5

glimepirid

(mg/day)

2

2

2

2

2

2

2

2

2

2

2

sitagliptin

(mg/day)

100

linagliptn

(mg/day)

5

5

5

5

5

5

omarigliptin

(mg/week)

25

25

25

25

25

pioglitazone

(mg/day)

15

30

30

30

metoformin

(mg/day)

1000

1000

1000

1000

1000

1000

1000

↑ Liver Biopsy