Skip to main content
Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications

Fig. 5

Insulin resistance induced inflammation. Insulin resistance in adipose tissue induces macrophage infiltration, developing an inflammatory state. In the insulin signaling pathway (IRS-1/2:PI3K:AKT:mTORC2) the MCP1 gene is suppressed by mTORC2 in adipose. In situations of insulin resistance, the downregulation of insulin signaling with reduced activity of mTORC2 will derepress MCP1 and will attract monocytes to adipose tissue, which will be converted into M1 macrophage

Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us