GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Table 1 Baseline characteristics of participants

	Total	rs780094			rs780093			rs1260326
	Total	CC (n = 2543)	CT (n = 4169)	TT (n = 1879)	CC (n = 2509)	CT (n = 4180)	TT (n = 1902)	CC (n = 2478)	CT (n = 4174)	TT (n = 1939)
With MetS	50.9%	28.1%	49%	23%*	28.2%	48%	23.8%*	27.4%	49.0%	23.6%*
Without MetS	49.1%	32.5%	47.1%	20.4%*	31.6%	48.2%	20.2%*	31.4%	47.7%	20.9%*
Male	42.6%	30.9%	47.8%	21.2%	30.8%	47.5%	21.6%	30.3%	48.0%	21.8%
Female	57.4%	29.7%	48.0%	22.2%	29.3%	48.4%	22.3%	28.8%	48.5%	22.7%
Smoking never	83%	30.6%	47.9%	21.5%	30.3%	48.0%	21.7%	29.7%	48.4%	21.9%
Ex-smoker and smoker	17%	28.0%	48.9%	23.1%	28.0%	49.0%	23.0%	27.8%	48.2%	23.9%
Age (years)	39 ± 16	39 ± 17	39 ± 16	40 ± 17	39 ± 17	39 ± 16	40 ± 17	39 ± 17	39 ± 16	39.5 ± 16.6
WC (cm)	85 ± 21 (53.3%)^a	85 ± 21	85 ± 21	85 ± 22	85 ± 22	85 ± 21	85 ± 22	85 ± 22	85 ± 21	85.4 ± 21.5
HDL-C (mg/dl)	42 ± 14 (69.8%)^b	43 ± 14	42 ± 14	42 ± 15	43 ± 14	42 ± 14	42 ± 14	43 ± 14	42 ± 14	42 ± 14
TG (mg/dl)	137 ± 86 (41.8%)^c	125 ± 75	139 ± 88	150 ± 91^†	126 ± 81	137 ± 84	152 ± 92^†	125 ± 74	138 ± 88	151 ± 92^†
FBS (mg/dl)	89 ± 25 (22.3%)^d	90 ± 26	89 ± 23	88 ± 27	90 ± 27	89 ± 23	89 ± 27	90 ± 27	89.4 ± 23.1	88.8 ± 26.5
SBP (mmHg)	110 ± 26(28.8%)^e	110 ± 26	110 ± 25	111 ± 27	110 ± 26	110 ± 25	111 ± 26	110 ± 26	110 ± 26	111.1 ± 26
DBP (mmHg)	73 ± 17 (28.8%)^e	72 ± 17	73 ± 17	73 ± 18	72 ± 18	73 ± 17	73 ± 18	72 ± 18	72 ± 17	73 ± 17

From the 6th row onwards, data are presented as mean ± SD
^aFrequency of subjects with high waist circumference: waist circumference ≥ 90 cm for both genders
^bFrequency of subjects low HDL-C: HDL-C < 40 mg/dl in men and < 50 mg/dl in women and drug treatment
^cFrequency of subjects high TG: TG ≥ 150 mg/dl and drug treatment
^dFrequency of subjects high FBS: FBS ≥ 100 mg/dl and drug treatment
^eFrequency of subjects high blood pressure: SBP ≥ 130 mmHg and DBP ≥ 85 mmHg and drug treatment
^*Frequency differences of genotypes between MetS and without MetS, P < 0.05
^†TT vs. CC, P < 0.05 and TT vs CT, P < 0.05

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