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Table 2 Characteristics of Brazilian women with PCOS in the studies included in the systematic review

From: Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Name, Year BMI (PCOS/controls) Waist circumference (cm) (PCOS /controls) Blood pressure (mmHg) (PCOS/controls) Lipid profile (PCOS/controls) Glucose (mmol/L) (PCOS/controls) HOMA-IR (PCOS/controls)
BMI-unmatched studies
Avila et al. 2014 [30] 30.6 ± 9.3/– NA NA NA NA NA
Azevedo et al. 2011 [23] 29.3 ± 6.7/24.1 ± 4.4* 91.2 ± 15.7/77.1 ± 9.6* SBP: 114.8 ± 13.3/111.5 ± 10.7*
DBP: 72.6 ± 10.7/72.1 ± 10.3
TC (mmol/L):
4.82 ± 1.09/4.57 ± 1.19
HDL (mmol/L):
1.05 ± 0.29/1.39 ± 0.49*
LDL (mmol/L):
NA
TGL (mmol/L):
1.56 ± 0.91/1.13 ± 0.6 *
4.64 ± 0.67/4.25 ± 0.62* NA
Carvalho et al. 2017 [31] 30.1 ± 5.4/ 23.2 ± 4.23* 98.0 (17.0)/71.5 (16.0)* NA NA 4.83 ± 0.4/ 4.7 ± 0.58 3.54(4.8)/1.68(1.6)*
Cerqueira et al. 2010 [24] 27.7 ± 5.4/ 24 ± 4.2* 84.5 ± 11.3/ 78.9 ± 10.0* SBP: 117.5 ± 11.9/104.0 ± 10.3*
DBP: 77.7 ± 9.8/68.7 ± 8.1*
TC (mmol/L):
4.57 ± 0.81/4.11 ± 0.76*
HDL (mmol/L):
1.16 ± 0.24/ 1.41 ± 0.43*
LDL (mmol/L):
2.29 ± 0.92/2.14 ± 0.75
TGL (mmol/L):
1.3 ± 0.78/0.94 ± 0.43*
4.88 ± 0.68/4.68 ± 0.41* 3.6 ± 3.7/1.9 ± 0.9*
Costa et al. 2012 [29] 29.6 ± 6.6/– NA SBP:115.5 ± 13.0/–
DBP:73.3 ± 10.3/–
TC (mmol/L):
4.88 ± 1.08/–
HDL (mmol/L):
01.14 ± 0.28/–
LDL (mmol/L):
3.11 ± 1.07/–
TGL (mmol/L): 1.54 ± 0.81/–
4.62 ± 0.68/– NA
de Medeiros et al. 2014 [48] 29.9 ± 7.0/– 88.0 ± 16.3/– NA NA 5.11 ± 0.78/– 1.93 ± 1.21/–
Gabrielli et al. 2012 [26] 24.2 (17.7–30.7)/ 24.1 (18.1–30.1) 74 (56–92)/75 (60–90) SBP: 119 (99–139)/122 (102–142)
DBP: 74 (60–88)/ 74 (59.5–89.5)
NA NA NA
Graff et al. 2017 [44] 29.4 ± 6.4/27.2 ± 5.8* 86.6 ± 14.1/83.6 ± 12.3 SBP:118.2 ± 13.0/112.4 ± 11.1*
DBP:77.4 ± 9.9/72.8 ± 10.0*
TC (mmol/L):
4.49 ± 0.89/4.5 ± 0.79
HDL (mmol/L):
1.18 ± 0.31/1.31 ± 0.28*
LDL (mmol/L):
2.75 ± 0.71/2.72 ± 0.63
TGL (mmol/L):
0.99(0.69–1.53) /0.87(0.6–1.16)
4.85 ± 0.47/4.82 ± 0.44 3.4(1.8–4.7)/2.1(1.5–2.8)*
Kogure et al. 2012 [32] 28.7 ± 4.4/27.1 ± 5.1 NA NA TC (mmol/L):
5.42 ± 1.24/5.47 ± 1.19
HDL (mmol/L):
1.38 ± 0.31/1.52 ± 0.28
LDL (mmol/L): 3.29 ± 0.92/3.4 ± 0.96
TGL (mmol/L): 1.65 ± 0.93/1.19 ± 0.75*
5.82 ± 0.99/5.73 ± 1.09 2.3 ± 2.3/1.6 ± 0.8*
Maciel et al. 2014 [34] 29.6 ± 6.9/– 90.1 ± 15.2/– NA TC (mmol/L): 4.42 ± 0.82/–
HDL (mmol/L): 1.3 ± 0.36/–
LDL (mmol/L): 2.55 ± 0.67/–
TGL (mmol/L): 1.3 ± 0.7/–
4.95 ± 0.57/– 3.8 ± 3.3/–
Melo et al. 2011a [35] 31.3 ± 8.7/24.4 ± 4.9* 98.6 ± 17.7/84.8 ± 12.4 SBP:
121.5 ± 15.2/111.5 ± 10.8*
DBP:
7 8 ± 10.4/71.7 ± 8.2*
TC (mmol/L): 4.76 ± 1.04/4.93 ± 0.84
HDL (mmol/L): 1.16 ± 0.27/1.41 ± 0.28*
LDL (mmol/L): 2.9 ± 0.92/2.82 ± 0.72
TGL (mmol/L): 1.49 ± 0.82/0.95 ± 0.44*
5.17 ± 1.41/4.58 ± 0.49* 4.5 ± 4.9/ 1.5 ± 1.1*
Oliveira et al. 2013b [36] 30.2 ± 6.5/27.1 ± 6.2 NA SBP:
111.8 ± 12.0 / 107.3 ± 15.0
DBP:
70.2 ± 9.0/71 ± 13.5
TC (mmol/L): NA
HDL (mmol/L): 1.3 ± 0.38/1.49 ± 0.35
LDL (mmol/L): NA
TGL (mmol/L): 1.32 ± 0.91/1.31 ± 0.74
4.82 ± 0.97/4.54 ± 0.47 4.4 ± 6.8 / 2.1 ± 1.1
Pedroso et al. 2012 [37] 31.9 ± 8.2/– 99 ± 16.6) SBP:
122.5 ± 18.7/–
DBP:
79 ± 11/–
TC (mmol/L): 4.86 ± 1.01/–
HDL (mmol/L): 1.22 ± 0.32/–
LDL (mmol/L): 2.94 ± 0.87/–
TGL (mmol/L): 1.48 ± 0.84/–
5.04 ± 1.08/– NA
Pontes et al. 2012 [38] 31.8 ± 7.6/– 92.2 ± 16.0 SBP: 116.3 ± 14.4/–
DBP: 75.1 ± 10.4/–
TC (mmol/L): 4.73 ± 0.9/–
HDL (mmol/L): 1.21 ± 0.33/–
LDL (mmol/L):
2.90 ± 0.77/–
TGL (mmol/L):
1.43 ± 0.91/–
4.87 ± 0.38/– NA
Radavelli-Bagatini et al. 2013 [45] 31.0 ± 7.9/23.4 ± 4.6* 92.2 ± 18.8/74.5 ± 10.2* SBP: 124.6 ± 19.9/111.5 ± 13.0*
DBP: 79.2 ± 12.5/71.8 ± 10.6*
TC (mmol/L):
4.81 ± 1.16/4.24 ± 0.9*
HDL (mmol/L): 1.32 ± 0.28/1.52 ± 0.36*
LDL (mmol/L): 2.95 ± 0.98/2.09 ± 0.72*
TGL (mmol/L): NA
NA NA
Ramos et al. 2015 [46] 29.6 ± 6.4/ 27.6 ± 6.0* 89.2 ± 15.0/78.1 ± 11.5* NA NA 4.93 ± 0.68/4.91 ± 0.42 NA
Santana et al. 2004c [40] 29.18 ± 7.78/– 89.36 ± 15.23/– NA TC (mmol/L): 4.71 ± 0.98/–
HDL (mmol/L): 1.01 ± 0.2/–
LDL (mmol/L): 3.10 ± 0.86/–
TGL (mmol/L): 1.26 ± 0.67/–
4.48 ± 0.59/– NA
Soares et al. 2016 [27] 29.8 ± 6.1/– 95.4 ± 15.8/– NA TC (mmol/L): NA
HDL (mmol/L): 1.13 ± 0.35/–
LDL (mmol/L): 2.3(1.81–2.69)/–
TGL (mmol/L): 1.39(0.71–1.85)/–
4.38 ± 0.53/– 1.9(1.3–3.3)/–
Wanderley et al. 2018 [49] 29.9 ± 5.28/– 92.15 ± 10.72/– SBP: 123.15 ± 18.38/–
DBP: 79.13 ± 11.00/–
TC (mmol/L): 4.73 ± 0.9/–
HDL (mmol/L): 1.28 ± 0.33/–
LDL (mmol/L): 3.03 ± 0.85/–
TGL (mmol/L): 1.25 ± 0.67/–
4.87 ± 0.36/– NA
Wiltgen et al. 2010d [43] 31 ± 7.98/ 26.97 ± 3.6* 93.79 ± 18.81/ 79.83 ± 8.37* SBP: 123.1 ± 16.9/115.2 ± 9.5*
DBP: 78.9 ± 12.3/73.6 ± 8.3
TC (mmol/L): 4.72 ± 1.13/4.27 ± 0.95
HDL (mmol/L): 1.25 ± 0.29/1.42 ± 0.35
LDL (mmol/L): 2.85 ± 0.96/ 2.47 ± 0.81
TGL (mmol/L): 1.12 (0.76–1.6)/ 0.68 (0.47 – 1.05)*
5.02 ± 1.19/ 4.92 ± 0.45 4.53 (2.6–7.7)/ 2.14 (1.4–3.1)*
Xavier et al. 2018 [42] 28.8 ± 8.1/ 22.9 ± 5.9* 97.0(18.0)/ 82.4(20.0)* NA TC (mmol/L): 4.92 ± 0.94/ 4.55 ± 0.83*
HDL (mmol/L): 1.19 (0.49) / 1.39 (0.49)*
LDL (mmol/L): 2.97 ± 0.82/2.58 ± 0.72*
TGL (mmol/L): 1.11 (0.97) /0.93 (0.44)*
6.95 ± 11.2/5.78 ± 7.14 2.8 (1.8)/1.59 (1.2)*
BMI-matched studies
Costa et al. 2008 [25] 27.6 ± 5.8/26.7 ± 4.9 87.8 ± 14.3/83.6 ± 10.1 SBP: 118.9 ± 15.2/113.8 ± 10.9
DBP: 79.9 ± 8.9/73.4 ± 10.2*
TC (mmol/L): 4.37 ± 0.62/4.11 ± 0.83
HDL (mmol/L): 1.23 ± 0.34/ 1.54 ± 0.27*
LDL (mmol/L): 2.56 ± 0.65/2.21 ± 0.72*
TGL (mmol/L): 1.16 ± 0.55/1.06 ± 0.68
  
Lauria et al. 2013 [33] 27.64 ± 5.43/25.99 ± 5.51 91 (83–101)/94 (83–103) SBP:
120 (110–120)/120 (110–120)
DBP:
80 (70–80)/ 80 (70–80)
TC (mmol/L): 0000000000000004.37 (3.67–4.76)/3.67 (3.21–4.34)*
HDL (mmol/L): 1.11 (0.88–1.29)/1.01 (0.85–1.14)
LDL (mmol/L): 2.77 (2.3–3.26)/2.25 (1.76–2.87)*
TGL (mmol/L): 0.91 (0.73–1.22)/0.8 (0.65–1.06)
  
Rocha et al. 2011 [39] 29.1 ± 6.17/27.4 ± 6.9 NA NA TC (mmol/L): 4.68 ± 0.78/4.28 ± 0.4
HDL (mmol/L): 1.23 ± 0.45/1.51 ± 0.2*
LDL (mmol/L): 2.87 ± 0.65/2.63 ± 0.58
TGL (mmol/L): 1.34 ± 0.74/1.32 ± 0.4
  
Simões et al. 2017 [41] 28.0 ± 2.4/27.4 ± 2.4 NA NA NA   
Wiltgen et al. 2009 [47] 29.5 ± 7.5/29.4 ± 5.4 90.6 ± 16.1/ 85.5 ± 11.6* NA TC (mmol/L): 4.85 ± 1.11 / 4.2 ± 0.8*
HDL (mmol/L): 1.35 ± 0.27 / 1.32 ± 0.3
LDL (mmol/L) 3.07 ± 0.97/2.46 ± 0.69*
TGL (mmol/L): 1.1 (0.77–1.48)/0.73 (0.54–1.21)*
  
  1. aData are from A phenotype PCOS vs controls
  2. bWomen included in the control group had similar complaints as the ones from the PCOS group, but did not fulfill the diagnostic criteria
  3. cData are from baseline
  4. dData are from A plus B phenotypes PCOS vs controls
  5. * p < 0.05 between the groups. Continuous metabolic variables are not available from Tavares et al. 2019 [24]