Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

Table 2 Univariate linear regression analyses for serum soluble EGFR levels in T2DM patients and NGT subjects

	NGT			T2DM
	n	β	P	n	β	P
Serum adipsin (μg/mL)	47	0.035	0.815	106	0.095	0.332
Age (years)	47	0.093	0.533	106	− 0.398	< 0.001
Sex	47	0.050	0.740	106	− 0.005	0.960
BMI	47	0.155	0.299	106	0.252	0.009
Waist circumference (cm)	25	− 0.044	0.833	71	0.242	0.042
Systolic blood pressure (mmHg)	42	− 0.029	0.856	102	− 0.143	0.152
Diastolic blood pressure (mmHg)	42	− 0.022	0.891	102	0.064	0.523
Fasting blood glucose (mg/dL)	46	0.164	0.275	106	0.285	0.003
Fasting serum insulin (μIU/mL)	41	0.219	0.169	83	0.233	0.034
C-peptide (ng/mL)	29	0.087	0.654	100	0.250	0.012
HOMA-IR	41	0.229	0.151	83	0.317	0.004
CPR-index	29	0.085	0.662	100	0.135	0.180
HbA1c (%, mmol/mol)	45	0.212	0.152	106	0.364	< 0.001
Total cholesterol (mg/dL)	41	0.361	0.021	102	0.419	< 0.001
LDL-cholesterol (mg/dL)	45	0.030	0.845	105	0.201	0.040
HDL-cholesterol (mg/dL)	45	0.064	0.675	106	0.085	0.386
Triglycerides (mg/dL)	45	0.466	0.112	106	0.309	0.001
AST (IU/L)	45	0.309	0.039	106	0.130	0.184
ALT (IU/L)	45	0.214	0.158	106	0.113	0.247
γGTP (IU/L)	44	0.124	0.423	105	0.213	0.029
FIB4-index	27	− 0.102	0.614	95	0.050	0.628
eGFR (mL/min/1.73 m²)	47	− 0.342	0.018	106	0.135	0.168

BMI, Body mass index; EGFR, Epidermal growth factor receptor; eGFR, Estimated glomerular filtration rate; NGT, Normal glucose tolerance; T2DM, Type 2 diabetes

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