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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-ĸB pathway in diabetic nephropathy

Fig. 2

Knockdown of KCNQ1OT1 inhibited proliferation and fibrosis and promoted apoptosis in high glucose-induced HGMCs and HRGECs. High glucose-induced HGMCs and HRGECs were transfected with si-KCNQ1OT1. a The expression of KCNQ1OT1 was detected by qRT-PCR. b, c proliferation of HGMCs and HRGECs was determined by MTT assay. d apoptosis of HGMCs and HRGECs was determined by flow cytometry assay. Apoptotic rate: Annexin positive cells/all cells. e The expression of fibrosis-related proteins was detected by western blot assay in glucose-induced HGMCs and HRGECs. N = 3, *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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