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Table 2 Clinical criteria suggesting diagnosis of GCK-MODY

From: Update on clinical screening of maturity-onset diabetes of the young (MODY)

Fasting hyperglycemia (≥ 5.5 mmol/L or 100 mg/dL in 98% of patients)

Small (< 3 mmol/L or 60 mg/dL) increment in an OGTT

Persistent hyperglycemia (at least three separate occasions), stable over a period of months to years

HbA1c rarely exceeding 7.5%

Parents with a clinical diagnosis of type 2 diabetes with no complications or parents without a known diabetes diagnosis, but a mildly raised fasting blood glucose (range 5.5–8 mmol/L or 100–140 mg/dL) upon testing

  1. HbA1c hemoglobin A1c, OGTT oral glucose tolerance test