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Table 4 Perinatal outcomes according to the study groups, with respective unadjusted risk ratios (RRs) and 95% confidence intervals (CIs)

From: Maternal factors associated with hyperglycemia in pregnancy and perinatal outcomes: a Brazilian reference center cohort study

Perinatal outcomes

HIP

Control

RR

Missing

N (%)

N (%)

[95% CI]

Male

182 (53.53)

119 (51.97)

1.03 [0.90–1.17]

–

C-section

229 (67.35)

132 (57.64

1.19 [1.02–1.38]

–

First C-section

86 (38.91)

76 (58.91)

0.74 [0.62–0.86]

–

GA < 37 weeks

25 (7.35)

14 (6.11)

1.08 [0.84–1.38]

–

Apgar score 5th min < 7

10 (2.95)

9 (4.04)

0.89 [0.56–1.34]

7

Apgar score 10th min < 7

1 (0.30)

1 (0.45)

0.83 [0.21–3.32]

8

LGA

42 (12.57)

14 (6.17)

1.30 [1.10–1.54]

8

Macrosomia

36 (10.62)

13 (5.68)

1.26 [1.05–1.51]

1

Cephal/Abdom < 1.0

9 (2.71)

7 (3.10)

0.94 [0.61–1.46]

11

Ponderal index ≥ 2.98

112 (33.43)

60 (26.55)

1.14 [0.99–1.31]

8

BW/GA Z-score > 2.0

16 (4.78)

1 (0.44)

1.61 [1.40–1.84]

8

Placental index > 0.21

56 (17.50)

32 (15.61)

1.05 [0.88–1.26]

44

Malformation

10 (3.09)

6 (2.84)

1.03 [0.70–1.52]

34

Hematocrit > 65.0%

7 (2.38)

0 (0.00)

1.70 [1.58–1.83]

74

Hematocrit > 55.0%

48 (16.33)

18 (8.96)

1.27 [1.07–1.50]

74

Bilirubin > 4.0 mg/dL

11 (3.61)

7 (3.37)

1.03 [0.71–1.50]

56

Resuscitation at birth

60 (17.80)

38 (16.74)

1.03 [0.87–1.23]

5

Respiratory distressa

24 (7.59)

13 (6.53)

1.06 [0.83–1.36]

54

Phototherapy

84 (26.09)

52 (25.49)

1.01 [0.87–1.18]

43

Sepsis

1 (0.32)

0 (0.00)

1.63 [1.52–1.75]

54

NICU

6 (1.83)

7 (3.2)

0.76 [0.42–1.38]

24

Perinatal death

1 (0.31)

1 (0.51)

0.81 [0.20–3.25]

53

Hospital stay ≥ 4 days

80 (25.24)

54 (25.23)

1.00 [0.85–1.17]

38

Any APOb

112 (32.94)

60 (26.20)

1.13 [1.00–1.30]

–

  1. HIP hyperglycemia in pregnancy (GDM + MGH), GA gestational age, SGA small for gestational age, AGA adequate for gestational age, LGA large for gestational age, Cephal/Abdom cephalic/abdominal ratio, BW birthweight, NICU neonatal intensive care unit
  2. aRespiratory distress—respiratory distress syndrome or meconium aspiration syndrome or persistent pulmonary hypertension or transient tachypnoea of the newborn
  3. bAny APO—any of the following: preterm delivery, LGA, macrosomia, ponderal index ≥ 2.98, Apgar 5th min < 7, malformation, hospital stay ≥ 4 days or perinatal death [fetal OR neonatal until the 28th day]