Table 4 Association between quartiles of circulating Nrg4 and 25(OH)D and risk of DPN in all nT2DM patients

Circulating Nrg4 level

 Circulating Nrg4 (ng/ml)

1.18 ± 0.31

2.14 ± 0.31

3.26 ± 0.33

5.18 ± 1.08

0.000

 Prevalence of DPN

28 (68.29)

19 (46.34)

16 (39.02)

13 (31.71)

0.006

 Model 1

1

0.401 (0.163–0.986) 0.047

0.297 (0.120–0.738) 0.009

0.216 (0.085–0.546) 0.001

0.008

 Model 2

1

0.443 (0.173–1.134) 0.089

0.384 (0.148–0.996) 0.049

0.250 (0.095–0.659) 0.005

0.040

 Model 3

1

0.336 (0.102–1.104) 0.072

0.282 (0.082–0.966) 0.044

0.115 (0.032–0.417) 0.001

0.026

 Model 4

1

0.363 (0.109–1.208) 0.099

0.297 (0.085–1.037) 0.057

0.100 (0.026–0.392) 0.001

0.027

 Model 5

1

0.304 (0.086–1.071) 0.064

0.213 (0.053–0.865) 0.030

0.116 (0.027–0.494) 0.004

0.047

Circulating 25(OH)D level

 Circulating 25(OH)D (ng/ml)

10.44 ± 2.16

14.25 ± 0.61

16.69 ± 0.68

22.77 ± 4.22

0.000

 Prevalence of DPN

21 (51.22)

22 (53.66)

23 (56.10)

10 (24.39)

0.013

 Model 1

1

1.103 (0.463–2.624) 0.825

1.103 (0.714–1.704) 0.658

0.675 (0.493–0.923) 0.014

0.026

 Model 2

1

1.139 (0.472–2.745) 0.773

1.091 (0.693–1.716) 0.707

0.681 (0.493–0.940) 0.020

0.032

 Model 3

1

0.787 (0.287–2.160) 0.642

1.081 (0.627–1.864) 0.779

0.586 (0.396–0.867) 0.007

0.040

 Model 4

1

0.662 (0.221–1.982) 0.461

1.060 (0.604–1.860) 0.840

0.564 (0.367–0.868) 0.009

0.028

 Model 5

1

0.673 (0.209–2.173) 0.508

1.103 (0.622–1.954) 0.738

0.586 (0.375–0.918) 0.020

0.098