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Table 4 Association between quartiles of circulating Nrg4 and 25(OH)D and risk of DPN in all nT2DM patients

From: Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 P for trend
Circulating Nrg4 level
 Circulating Nrg4 (ng/ml) 1.18 ± 0.31 2.14 ± 0.31 3.26 ± 0.33 5.18 ± 1.08 0.000
 Prevalence of DPN 28 (68.29) 19 (46.34) 16 (39.02) 13 (31.71) 0.006
 Model 1 1 0.401 (0.163–0.986) 0.047 0.297 (0.120–0.738) 0.009 0.216 (0.085–0.546) 0.001 0.008
 Model 2 1 0.443 (0.173–1.134) 0.089 0.384 (0.148–0.996) 0.049 0.250 (0.095–0.659) 0.005 0.040
 Model 3 1 0.336 (0.102–1.104) 0.072 0.282 (0.082–0.966) 0.044 0.115 (0.032–0.417) 0.001 0.026
 Model 4 1 0.363 (0.109–1.208) 0.099 0.297 (0.085–1.037) 0.057 0.100 (0.026–0.392) 0.001 0.027
 Model 5 1 0.304 (0.086–1.071) 0.064 0.213 (0.053–0.865) 0.030 0.116 (0.027–0.494) 0.004 0.047
Circulating 25(OH)D level
 Circulating 25(OH)D (ng/ml) 10.44 ± 2.16 14.25 ± 0.61 16.69 ± 0.68 22.77 ± 4.22 0.000
 Prevalence of DPN 21 (51.22) 22 (53.66) 23 (56.10) 10 (24.39) 0.013
 Model 1 1 1.103 (0.463–2.624) 0.825 1.103 (0.714–1.704) 0.658 0.675 (0.493–0.923) 0.014 0.026
 Model 2 1 1.139 (0.472–2.745) 0.773 1.091 (0.693–1.716) 0.707 0.681 (0.493–0.940) 0.020 0.032
 Model 3 1 0.787 (0.287–2.160) 0.642 1.081 (0.627–1.864) 0.779 0.586 (0.396–0.867) 0.007 0.040
 Model 4 1 0.662 (0.221–1.982) 0.461 1.060 (0.604–1.860) 0.840 0.564 (0.367–0.868) 0.009 0.028
 Model 5 1 0.673 (0.209–2.173) 0.508 1.103 (0.622–1.954) 0.738 0.586 (0.375–0.918) 0.020 0.098
  1. Data are expressed as OR (95% CI) + P value, unless stated otherwise
  2. Model 1: crude model
  3. Model 2: Model 1 + sex, age, BMI
  4. Model 3: Model 2 + SBP, DBP, TC, TG, FBG, PBG, HbA1C, FIns, HOMA-IR
  5. Model 4: Model 3 + DR, DN, PAD
  6. Model 5: Model 4 + 25(OH)D or Nrg4
  7. OR odds ratio; CI confidence interval