Table 1 Comparative parameters at baseline and day 7 after dapagliflozin administration

Age (years)

68.5 ± 2.1

–

–

Male gender (%)

66.7

–

–

Body weight (kg)

68.6 ± 2.7

66.0 ± 2.5

< 0.001

BMI (kg/m²)

27.1 ± 0.7

26.1 ± 0.7

< 0.001

Systolic BP (mmHg)

139 ± 4

136 ± 5

0.210

Diastolic BP (mmHg)

76 ± 3

70 ± 3

0.012

Heart rate (beats/min)

75 ± 2

73 ± 3

0.450

Hemoglobin (g/dL)

11.1 (9.6–13.2)

11.3 (10.0–13.9)

0.002

Hematocrit (%)

32.9 (29.1–38.4)

34.3 (30.4–39.6)

0.009

Plasma glucose (mg/dL)

145 (116–206)

154 (115–184)

0.459

HbA1c (%)

7.2 ± 0.2

–

–

BNP (pg/mL)

91.6 (20.9–232.1)

60.8 (16.3–146.0)

< 0.001

Serum albumin (g/dL)

3.5 (2.8–4.0)

3.7 (3.0–4.0)

0.002

BUN (mg/dL)

26.2 (17.3–42.6)

24.8 (19.4–39.8)

0.183

Serum creatinine (mg/dL)

1.9 (1.4–2.3)

1.8 (1.3–2.6)

0.004

eGFR (mL/min/1.73 m²)

27.9 (19.2–42.0)

29.3 (17.9–39.6)

0.003

Uric acid (mg/dL)

6.6 ± 0.3

6.3 ± 0.2

0.031

Serum Na⁺ (mEq/L)

141 (138–142)

141 (137–143)

0.402

Serum K⁺ (mEq/L)

4.4 ± 0.1

4.2 ± 0.1

0.045

Proteinuria (g/day)^a

1.3 (0.3–5.6)

–

ICW (L)

21.8 ± 0.9

20.7 ± 0.8

< 0.001

ECW (L)

15.5 ± 0.7

14.3 ± 0.6

< 0.001

TBW (L)

37.2 ± 1.6

35.0 ± 1.4

< 0.001

ICW/TBW

0.585 ± 0.004

0.591 ± 0.003

< 0.001

ECW/TBW

0.415 ± 0.004

0.409 ± 0.003

< 0.001

Concomitant diuretics (%)

66.7

 Loop diuretics (%)

66.7

–

–

 MR antagonist (%)

19.4

–

–

 Thiazide diuretics (%)

8.3

–

–

 Tolvaptan (%)

11.1

–

–