Adipose tissue gene expression of long non-coding RNAs; MALAT1, TUG1 in obesity: is it associated with metabolic profile and lipid homeostasis-related genes expression?

Table 4 Unadjusted and adjusted correlation of TUG1 gene expression in SAT and VAT of the whole population study with energy homeostasis-related genes

Characteristics	lncRNA TUG1 in SAT		lncRNA TUG1 in VAT
	Whole population		Whole population
	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient
PPARγ	− 0.0196	− 0.119	0.090	0.021
PGC1α	0.466^b	0.497^b	0.155	0.191
SREBP	0.407^a	0.465^b	− 0.059	− 0.041
FAS	0.342^a	0.378^a	− 0.093	0.007
ACC	0.415^b	0.411^b	− .0143	− 0.049
LncRNA MALAT1	0.299	0.346^a	− 0.380^a	− 0.324^a

SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; TUG1, taurine upregulated gene 1; PPARγ, peroxisome proliferator-activated receptor gamma; PGC1α, PPARγ coactivator-1 alpha; SREBP-1, sterol regulatory element-binding protein α; FAS, fatty acid synthase; ACC, acetyl-CoA carboxylase; HOMA-IR, homeostasis model assessment of insulin resistance
^a Correlation is significant at the 0.05 level (2-tailed)
^b Correlation is significant at the 0.01 level (2-tailed)

ISSN: 1758-5996