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Table 2 CpG Sites with highest  % methylation differences and corresponding gene expression

From: Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Gene symbol Probe ID CpG location p-value (Ob vs. L) Methylation difference (Ob − L) Probeset ID p-value (Ob vs. L) Fold change
NEDD4L cg18971282b 5′UTR <0.01 −16.6 212448_at 0.03 3.68
MAPT cg18228076b 5′UTR 0.04 −4.7 233117_at 0.01 3.14
LFNG cg20572537a Body 0.04 −3.8 215270_at 0.03 2.26
SMARCA1 cg10076009b Body 0.05 −3.7 215294_s_at 0.03 2.29
PARVA cg15123662b Body 0.02 −3.4 235279_at 0.04 2.31
PDZD2 cg22461201b TSS1500 0.01 −3.2 209493_at 0.04 2.70
EXOC4 cg25467879b Body 0.02 −3.2 240528_s_at 0.01 2.32
SIPA1L1 cg02058870b 5′UTR 0.04 −2.6 202254_at 0.03 4.60
ACSF3 cg05521982b TSS1500 0.02 −2.4 227464_at 0.02 1.79
GNG7 cg08481112b 5′UTR 0.01 −2.0 228831_s_at 0.04 2.01
cg19382697a 5′UTR   −1.1
KCNT1 cg03358588b Body 0.05 1.5 1569462_x_at 0.01 −2.61
cg01841415b Body 0.03 2.0
cg13463516b Body 0.02 3.2
OSBPL1A cg27638913b Body 0.04 3.3 1554646_at 0.04 −1.87
PPP2R2C cg23195028b Body 0.01 3.3 223573_s_at 0.01 −4.64
JPH3 cg04769798a Body 0.05 3.3 229294_at 0.01 −2.64
GOLGA3 cg23755933a 3′UTR 0.03 3.3 1554987_at 0.04 −1.54
TTLL9 cg09044785b 5′UTR 0.05 3.7 234337_at 0.02 −1.41
BAI1 cg25473866b Body 0.01 2.1 206083_at −1.68
cg21934273a Body 0.01 3.8
SAMD3 cg09345868b 5′UTR 0.01 4.3 1553876_at 0.04 −1.70
PPP2R1B cg09085632a TSS200 0.04 5.6 222351_at 0.02 −2.33
  1. Data are presented as mean ± SD
  2. Methylation difference:  % methylation (Ob) −  % Methylation (L); values for  % Methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. The top hypo- and hypermethylated probes are presented with corresponding gene probe
  3. aInfinium I probe design
  4. bInfinium II probe design. Gene names are located in Additional file 4: Table S4