Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Table 2 CpG Sites with highest % methylation differences and corresponding gene expression

Gene symbol	Probe ID	CpG location	p-value (Ob vs. L)	Methylation difference (Ob − L)	Probeset ID	p-value (Ob vs. L)	Fold change
NEDD4L	cg18971282^b	5′UTR	<0.01	−16.6	212448_at	0.03	3.68
MAPT	cg18228076^b	5′UTR	0.04	−4.7	233117_at	0.01	3.14
LFNG	cg20572537^a	Body	0.04	−3.8	215270_at	0.03	2.26
SMARCA1	cg10076009^b	Body	0.05	−3.7	215294_s_at	0.03	2.29
PARVA	cg15123662^b	Body	0.02	−3.4	235279_at	0.04	2.31
PDZD2	cg22461201^b	TSS1500	0.01	−3.2	209493_at	0.04	2.70
EXOC4	cg25467879^b	Body	0.02	−3.2	240528_s_at	0.01	2.32
SIPA1L1	cg02058870^b	5′UTR	0.04	−2.6	202254_at	0.03	4.60
ACSF3	cg05521982^b	TSS1500	0.02	−2.4	227464_at	0.02	1.79
GNG7	cg08481112^b	5′UTR	0.01	−2.0	228831_s_at	0.04	2.01
GNG7	cg19382697^a	5′UTR		−1.1	228831_s_at	0.04	2.01
KCNT1	cg03358588^b	Body	0.05	1.5	1569462_x_at	0.01	−2.61
	cg01841415^b	Body	0.03	2.0
	cg13463516^b	Body	0.02	3.2
OSBPL1A	cg27638913^b	Body	0.04	3.3	1554646_at	0.04	−1.87
PPP2R2C	cg23195028^b	Body	0.01	3.3	223573_s_at	0.01	−4.64
JPH3	cg04769798^a	Body	0.05	3.3	229294_at	0.01	−2.64
GOLGA3	cg23755933^a	3′UTR	0.03	3.3	1554987_at	0.04	−1.54
TTLL9	cg09044785^b	5′UTR	0.05	3.7	234337_at	0.02	−1.41
BAI1	cg25473866^b	Body	0.01	2.1	206083_at	−	−1.68
BAI1	cg21934273^a	Body	0.01	3.8	206083_at	−	−1.68
SAMD3	cg09345868^b	5′UTR	0.01	4.3	1553876_at	0.04	−1.70
PPP2R1B	cg09085632^a	TSS200	0.04	5.6	222351_at	0.02	−2.33

Data are presented as mean ± SD
Methylation difference: % methylation (Ob) − % Methylation (L); values for % Methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. The top hypo- and hypermethylated probes are presented with corresponding gene probe
^aInfinium I probe design
^bInfinium II probe design. Gene names are located in Additional file 4: Table S4