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Table 2 CpG Sites with highest  % methylation differences and corresponding gene expression

From: Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Gene symbol

Probe ID

CpG location

p-value (Ob vs. L)

Methylation difference (Ob − L)

Probeset ID

p-value (Ob vs. L)

Fold change

NEDD4L

cg18971282b

5′UTR

<0.01

−16.6

212448_at

0.03

3.68

MAPT

cg18228076b

5′UTR

0.04

−4.7

233117_at

0.01

3.14

LFNG

cg20572537a

Body

0.04

−3.8

215270_at

0.03

2.26

SMARCA1

cg10076009b

Body

0.05

−3.7

215294_s_at

0.03

2.29

PARVA

cg15123662b

Body

0.02

−3.4

235279_at

0.04

2.31

PDZD2

cg22461201b

TSS1500

0.01

−3.2

209493_at

0.04

2.70

EXOC4

cg25467879b

Body

0.02

−3.2

240528_s_at

0.01

2.32

SIPA1L1

cg02058870b

5′UTR

0.04

−2.6

202254_at

0.03

4.60

ACSF3

cg05521982b

TSS1500

0.02

−2.4

227464_at

0.02

1.79

GNG7

cg08481112b

5′UTR

0.01

−2.0

228831_s_at

0.04

2.01

cg19382697a

5′UTR

 

−1.1

KCNT1

cg03358588b

Body

0.05

1.5

1569462_x_at

0.01

−2.61

cg01841415b

Body

0.03

2.0

cg13463516b

Body

0.02

3.2

OSBPL1A

cg27638913b

Body

0.04

3.3

1554646_at

0.04

−1.87

PPP2R2C

cg23195028b

Body

0.01

3.3

223573_s_at

0.01

−4.64

JPH3

cg04769798a

Body

0.05

3.3

229294_at

0.01

−2.64

GOLGA3

cg23755933a

3′UTR

0.03

3.3

1554987_at

0.04

−1.54

TTLL9

cg09044785b

5′UTR

0.05

3.7

234337_at

0.02

−1.41

BAI1

cg25473866b

Body

0.01

2.1

206083_at

−

−1.68

cg21934273a

Body

0.01

3.8

SAMD3

cg09345868b

5′UTR

0.01

4.3

1553876_at

0.04

−1.70

PPP2R1B

cg09085632a

TSS200

0.04

5.6

222351_at

0.02

−2.33

  1. Data are presented as mean ± SD
  2. Methylation difference:  % methylation (Ob) −  % Methylation (L); values for  % Methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. The top hypo- and hypermethylated probes are presented with corresponding gene probe
  3. aInfinium I probe design
  4. bInfinium II probe design. Gene names are located in Additional file 4: Table S4