|
Gene symbol
|
Probe ID
|
CpG location
|
p-value (Ob vs. L)
|
Methylation difference (Ob − L)
|
Probeset ID
|
p-value (Ob vs. L)
|
Fold change
|
|---|
|
NEDD4L
|
cg18971282b
|
5′UTR
|
<0.01
|
−16.6
|
212448_at
|
0.03
|
3.68
|
|
MAPT
|
cg18228076b
|
5′UTR
|
0.04
|
−4.7
|
233117_at
|
0.01
|
3.14
|
|
LFNG
|
cg20572537a
|
Body
|
0.04
|
−3.8
|
215270_at
|
0.03
|
2.26
|
|
SMARCA1
|
cg10076009b
|
Body
|
0.05
|
−3.7
|
215294_s_at
|
0.03
|
2.29
|
|
PARVA
|
cg15123662b
|
Body
|
0.02
|
−3.4
|
235279_at
|
0.04
|
2.31
|
|
PDZD2
|
cg22461201b
|
TSS1500
|
0.01
|
−3.2
|
209493_at
|
0.04
|
2.70
|
|
EXOC4
|
cg25467879b
|
Body
|
0.02
|
−3.2
|
240528_s_at
|
0.01
|
2.32
|
|
SIPA1L1
|
cg02058870b
|
5′UTR
|
0.04
|
−2.6
|
202254_at
|
0.03
|
4.60
|
|
ACSF3
|
cg05521982b
|
TSS1500
|
0.02
|
−2.4
|
227464_at
|
0.02
|
1.79
|
|
GNG7
|
cg08481112b
|
5′UTR
|
0.01
|
−2.0
|
228831_s_at
|
0.04
|
2.01
|
|
cg19382697a
|
5′UTR
| |
−1.1
|
|
KCNT1
|
cg03358588b
|
Body
|
0.05
|
1.5
|
1569462_x_at
|
0.01
|
−2.61
|
|
cg01841415b
|
Body
|
0.03
|
2.0
|
|
cg13463516b
|
Body
|
0.02
|
3.2
|
|
OSBPL1A
|
cg27638913b
|
Body
|
0.04
|
3.3
|
1554646_at
|
0.04
|
−1.87
|
|
PPP2R2C
|
cg23195028b
|
Body
|
0.01
|
3.3
|
223573_s_at
|
0.01
|
−4.64
|
|
JPH3
|
cg04769798a
|
Body
|
0.05
|
3.3
|
229294_at
|
0.01
|
−2.64
|
|
GOLGA3
|
cg23755933a
|
3′UTR
|
0.03
|
3.3
|
1554987_at
|
0.04
|
−1.54
|
|
TTLL9
|
cg09044785b
|
5′UTR
|
0.05
|
3.7
|
234337_at
|
0.02
|
−1.41
|
|
BAI1
|
cg25473866b
|
Body
|
0.01
|
2.1
|
206083_at
|
−
|
−1.68
|
|
cg21934273a
|
Body
|
0.01
|
3.8
|
|
SAMD3
|
cg09345868b
|
5′UTR
|
0.01
|
4.3
|
1553876_at
|
0.04
|
−1.70
|
|
PPP2R1B
|
cg09085632a
|
TSS200
|
0.04
|
5.6
|
222351_at
|
0.02
|
−2.33
|
- Data are presented as mean ± SD
- Methylation difference: % methylation (Ob) − % Methylation (L); values for % Methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. The top hypo- and hypermethylated probes are presented with corresponding gene probe
- aInfinium I probe design
- bInfinium II probe design. Gene names are located in Additional file 4: Table S4
