Fig. 2

a Top Canonical Pathways from Ingenuity Pathway Analysis. p-values were determined via Right-Tailed Fisher’s Exact Test and -log transformed. A larger–log(p-value) indicates a lesser likelihood that the grouping of significant genes within the pathway is by random chance. Numbers within bars indicate the ratio of significant genes to total genes within the pathway. b Modified IPA PI3K/AKT signaling with obesity. Genes identified in the integrated analysis of global methylation and global gene expression involved in the PI3K/AKT signaling pathway. Gray shading indicates mRNA upregulation in obesity. Black shading indicates mRNA downregulation in obesity. Corresponding Beta-values, p-values and fold changes are located in Table 3. Figure created using Ingenuity Pathway Analysis