Skip to main content

Table 4 Effects of chloroquine vs. placebo over 24 months (off either, i.e. washout, months 12–24)

From: Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

VariableBaseline6 months12 months24 monthsP value
Waist (cm)
 Chloroquine110.4 ± 10.5112.5 ± 12.6112.6 ± 13.6113.2 ± 16.60.5578 (12 m)
 Placebo108.9 ± 11.8110.4 ± 13.8109.8 ± 12.4108.9 ± 15.9 
Weight (kg)
 Chloroquine102.9 ± 16.7102.9 ± 16.7103.1 ± 19.2105.9 ± 20.40.1323
 Placebo99.7 ± 18.598.7 ± 18.599.2 ± 17.8100.5 ± 21.20.1909 (t test 24 m)
Fasting glucose
 Chloroquine5.48 ± 0.535.36 ± 0.555.30 ± 0.515.58 ± 0.730.2741 (12 m)
 Placebo5.52 ± 0.645.52 ± 0.625.51 ± 0.715.63 ± 0.740.0930 (t test 12 m)
Glucose AUC
 Chloroquine16.32 ± 2.4615.94 ± 2.2416.17 ± 2.5816.97 ± 3.200.2537
 Placebo16.54 ± 3.4916.87 ± 3.2916.43 ± 3.3417.50 ± 3.85 
Insulin AUC
 Chloroquine1202 ± 6811118 ± 5421143 ± 6031213 ± 7160.2479
 Placebo1003 ± 5241054 ± 588995 ± 5701022 ± 613 
C peptide AUC
 Chloroquine7.46 ± 2.337.23 ± 2.107.16 ± 2.207.39 ± 2.430.2918
 Placebo6.49 ± 1.806.69 ± 2.066.46 ± 2.006.79 ± 2.06 
HOMA-IR
 Chloroquine3.89 ± 2.233.85 ± 2.213.57 ± 2.123.72 ± 3.530.8421
 Placebo3.54 ± 2.033.64 ± 2.083.30 ± 2.233.29 ± 2.26 
Matsuda index
 Chloroquine2.89 ± 1.722.88 ± 1.553.13 ± 2.313.43 ± 2.840.8997
 Placebo3.21 ± 1.893.07 ± 1.643.50 ± 2.143.56 ± 2.70 
Insulinogenic index
 Chloroquine1.40 ± 1.751.17 ± 0.871.24 ± 0.871.12 ± 0.890.4988
 Placebo1.05 ± 0.771.03 ± 0.671.09 ± 0.881.13 ± 1.62 
Glucagon AUC
 Chloroquine174.0 ± 63.5152.3 ± 60.3126.8 ± 43.3ND0.6126
 Placebo168.0 ± 60.6138.7 ± 46.7119.8 ± 36.2ND
Creatinine (μmol/L)
 Chloroquine68 ± 1467 ± 1566 ± 15ND0.7859
 Placebo66 ± 1665 ± 1765 ± 17  
ALT
 Chloroquine26 ± 1626 ± 1926 ± 15ND0.2056
 Placebo25 ± 1227 ± 1623 ± 9ND 
WBC count
 Chloroquine6.7 ± 1.86.3 ± 1.66.0 ± 1.5ND0.7249
 Placebo6.5 ± 1.76.3 ± 1.86.1 ± 1.9ND 
Hemoglobin
 Chloroquine13.6 ± 1.113.3 ± 1.113.2 ± 1.2ND0.8953
 Placebo13.8 ± 0.813.5 ± 0.913.5 ± 0.9ND 
  1. Data represent mean ± SD
  2. P values determined by mixed model approach to repeated measures except where indicated