Tables 4 Mean changes in metabolic indicators at the baseline and end of trial

− 29.2 ± 3.56^a,c

− 24.3 ± 3.54^a,c

− 8.7 ± 5.47

< 0.01

− 12.2 ± 1.86^c

− 11.6 ± 1.95^c

− 4.1 ± 1.12

0.14

2.1 ± 0.49^c

1.7 ± 0.64^c

− 0.57 ± 1.46

0.10

− 23.1 ± 2.03^a,c

− 20.1 ± 3.00^a,c

− 0.80 ± 3.84

< 0.001

− 7.1 ± 1.11^a,c

− 5.0 ± 0.67^a,c

− 0.37 ± 1.23

< 0.001

0.19 ± 0.03^a,c

0.18 ± 0.03^a,c

− 0.02. ± 0.01

< 0.01

− 0.31 ± 0.04^a,c

− 0.28 ± 0.01^a,c

0.06 ± 0.05

< 0.001

− 14.4 ± 1.10^b,c

− 6.5 ± 0.60^c

− 2.8 ± 1.54

< 0.001

− 2.0 ± 0.29^b,c

− 0.8 ± 0.20^a,c

0.4 ± 0.22

< 0.001

− 0.9 ± 0.08^b,c

− 0.4 ± 0.06^a,c

− 0.02 ± 0.07

< 0.001

− 0.5 ± 0.08^a,c

− 0.4 ± 0.09^a,c

0.03 ± 0.21

< 0.01

− 0.25 ± 0.16

− 0.16 ± 0.17

− 0.04 ± 0.32

0.8

− 18.8 ± 8.98

− 14.5 ± 9.53

− 7.8 ± 6.24

0.65

− 0.75 ± 0.04^a,c

− 0.63 ± 0.07^a,c

− 0.01 ± 0.08

< 0.001

214.2 ± 20.02^a,c

198.0 ± 23.47^a,c

45.1 ± 19.34

< 0.001