Skip to main content

Table 3 Association of risk factors with insulin resistance in patients with different liver diseases

From: Insulin resistance exhibits varied metabolic abnormalities in nonalcoholic fatty liver disease, chronic hepatitis B and the combination of the two: a cross-sectional study

  CHB NAFLD CHB with NAFLD
Univariate Multivariate Univariate Multivariate Univariate Multivariate
P OR P OR (95% CI) P OR P OR (95% CI) P OR P OR (95% CI)
Age, years 0.786 1.03 0.83   0.23 0.93 0.38   0.242 0.86 0.76  
Male 0.004 0.45 0.23   0.24 1.22 0.20   1.000 1.01 0.52  
Obesitya < 0.001 4.45 < 0.001 2.97 (1.79–4.94) < 0.001 3.24 < 0.001 2.80 (1.93–4.05) < 0.001 2.79 < 0.001 3.23 (1.74–6.00)
Hypertensiona < 0.001 3.07 0.001 2.65 (1.48–4.74) 0.001 1.73 0.01 1.56 (1.11–2.20) 0.042 1.84 0.02 2.25 (1.17–4.30)
Hypercholesteremiaa 0.641 1.148 0.58   0.01 1.50 0.91   0.033 1.81 0.26  
Hypertriglyceridemiaa 0.001 2.403 0.64   0.08 1.32 0.58   0.828 0.91 0.39  
Low HDL-ca < 0.001 2.56 0.001 2.65 (1.52–4.64) < 0.001 1.87 < 0.001 2.08 (1.48–2.93) 0.904 1.07 0.33  
High LDL-ca 0.015 1.82 0.04 2.14 (1.03–4.45) < 0.001 1.73 0.01 1.70 (1.14–2.54) 0.022 1.89 0.34  
Hyperuricemiaa 0.001 2.18 0.03 1.78 (1.07–2.96) < 0.001 1.75 0.03 1.42 (1.04–1.94) 0.027 1.84 0.28  
ALT elevationa 0.002 2.04 < 0.001 3.12 (1.70–5.76) < 0.001 1.88 0.12   0.003 2.33 0.39  
AST elevationa 0.577 1.18 0.02 0.45 (0.24–0.86) < 0.001 1.98 0.20   < 0.001 3.24 0.004 2.99 (1.41–6.32)
ALB (g/L) 0.495 1.02 0.85   0.24 0.97 0.54   0.931 1.00 0.94  
Total bilirubin (μmol/L) 0.148 0.97 0.12   0.07 0.97 0.22   0.22 0.97 0.15  
  1. Data are expressed as n (%) and mean (standard deviation)
  2. NAFLD: nonalcoholic fatty liver disease; CHB: chronic hepatitis B; ALT: alanine aminotransferase; AST: aspartate aminotransferase; FBG: fasting blood glucose; FINS: serum insulin; ALB: albumin
  3. aObesity was defined as body mass index ≥ 25 kg/m2, Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg. Hypercholesterolemia was defined as a total CHOL level > 5.2 mmol/L. Hypertriglyceridemia was defined as a TG level > 1.7 mmol/L. A low HDL-C level was defined as an HDL-C level < 1.0 mmol/L. A high LDL-C level was defined as an LDL-C level > 3.4 mmol/L. Hyperuricemia was defined as males and females at > 420 and 360 µmol/L, respectively. The normal upper limit for ALT and AST were set to 40 and 37 U/L, respectively