Characterization of low molecular weight urinary proteins at varying time intervals in type 2 diabetes mellitus and diabetic nephropathy patients

Table 2 Concentration of low molecular weight urinary proteins in T2DM patients with and without secondary complications

Molecular weight in kDa	Control (mg/dl)	T2DM with 0–5 years (mg/dl)	T2DM with 5–10 years (mg/dl)	T2DM with 10–15 years (mg/dl)	T2DM with 15–20 years (mg/dl)	Micro albuminuria (mg/dl)	Diabetic nephropathy (mg/dl)	Non diabetic nephropathy (mg/dl)
13	1.5	3.01 ^NSa	12.37 ***ab	18.11 ***abc	26.82 ***abcd	99.93 ***abc,^NSe	318.54 ***abcdef	0.67 ^NSabcdefg
17	1.32	34.38 ***a	32.89 ***a^NSb	32.62 ***a^NSbc	37.64 ***a^NSbcd	175.92 ***abcde	217.48 **abcdef	0 ^NSabcdefg
23	15.42	15.42 ^NSa	16.76 ^NSab	17.81 ^NSabc	33.87 *a^NSbcd	76.15 *abcd e	158.39 *abcdef	0.32 ^NSabcdefg
24	2.42	5.42 ^NSa	7.69 ^NSab	7.88 ^NSabc	12.7 **a bcd	51.29 ***abcde	71.32 ***abcdef	0 ^NSabcdefg
28	7.21	7.21 ^Nsa	7.56 ^NSab	9.63 ^NSabc	13.28 *abc^NSd	109.35 ***abcde	71.83 ***abcdef	0.11 ^Nsabcdefg
35	1.94	3.65 ^Nsa	4.21 ^NSab	5.6 ^NSabc	6.44 ^NSabcd	45.68 ***abcde	52.09 ***abcdef	0 ^Nsabcdefg
37	1.25	7.52 *a	7.86 *a^NSb	8.21 *a^NSbc	12.23 **a bcd	45.73 ***abcde	69.43 ***abcdef	0 ^NSabcdefg
39	0.09	2.11 ^NSa	2.2 ^NSab	2.45 ^NSabc	3.05 ^NSabcd	28.97 ***abcde	41.83 ***abcdef	0 ^NSabcdefg
41	8.48	22.15 **a	23.14 **a^NSb	26.71 **a^NSbc	26.24 **a^NSbcd	149.25 ***abcde	246.93 ***abcdef	0 ^NSabcdefg
49	11.28	23.61 *a	23 *a^NSb	23.57 *a^NSbc	32.76 *a bcd	214.62 ***abcde	341.59 **abcdef	0.14 ^NSabcdefg
50	8.72	31.03 **a	31.5 **a^NSb	32.6 **a^NSbc	33.02 **a^NSbcd	172.18 ***abcde	216.61 **abcdef	0 ^NSabcdefg

The results are expressed as mean + SE and p < 0.05 is considered significant. * p < 0.05, ** p < 0.001, *** p < 0.0001
a—compared with control, b—compared with 0–5 years, T2DM, c—compared with 5–10 years T2DM, d—compared with 10–15 years T2DM, e—compared with 15–20 years T2DM, f—compared with microalbuminuria, g—compared with diabetic nephropathy
NS, non significant

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