Fig. 3

Infusion of SHED promotes restoration of pancreatic islets in T2DM rats. a Pancreas histology was studied via HE staining, observed under light microscopy and focused on islet structures. b Pancreatic islets were characterized by immunofluorescence according to the presence and distribution of insulin-producing (green) and glucagon-producing (red) cells in four groups of rats at 8 weeks after infusion. Images were composite overlays of the individually stained nuclei, insulin and glucagon. SHED and BMSCs injection significantly improved abnormalities in pancreatic islets. c The proportion of the irregular islets and the proportion of β-cells in 4 group. ***P<0.001