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Table 1 Staging of diabetic nephropathy

From: Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management


DN staging Tervaert et al. [11]

DN staging Gheith et al. [13]

Stage 1

Glomerular basement membrane thickening

From onset to 5 years. Borderline GFR, no albuminuria, hypertension. But kidney size increased by 20% along with an increase in renal plasma flow

Stage 2

Mild or severe mesangial expansion

From 2 years after onset with basement membrane thickening and mesangial prolieration, normal GFR and no clinical symptoms

Stage 3

Nodular sclerosis

5–10 years after onset with or without hypertension, with glomerular damage and microalbuminuria (30–300 mg/day)

Stage 4

Advanced diabetic glomerulosclerosis that includes tubulointerstitial lesions and vascular lesions

Irreversible proteinuria, sustained hypertension and GFR below 60 ml/min/1.73 m2

Stage 5

End-stage kidney disease with GFR < 15 ml/min/1.73 m2

  1. DN diabetic nephropathy, GFR glomerular filtration rate