Table 6 Analysis of the relationship between the MTHFR methylation pattern and the A1298C + C677T polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables
Hypermethylated | Partially methylated | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
677CC/1298AA (8) | 677CC/1298AC (10) + CC (3) | p | 677CT (11) + TT (3)/1298AA (14) | 677CT/1298AC (7) | p | 677CC/1298AA (13) | 677CC/298AC (12) + CC (5) | P | 677CT (21) + TT (2)/1298AA (23) | 677CT/1298AC (11) | P | ||
HbA1c | Mean ± SD Median | 9.4 ± 2.0 9.2 | 7.9 ± 2.8 7.1 | 0.0638 | 8.0 ± 1.3 8.1 | 7.9 ± 1.2 7.5 | 0.7653 | 7.8 ± 1.5 7.8 | 8.6 ± 1.8 9.2 | 0.1547 | 8.0 ± 2.0 7.5 | 8.9 ± 1.8 8.6 | |
Min.–Max. | 6.4‒3.0 | 5.3‒14.4 | 5.7‒1.1 | 6.5‒9.6 | 4.1‒10.3 | 4.3‒11.0 | 4.7‒12.7 | 5.7‒11.2 | 0.1262 | ||||
GLIC | Mean ± SD Median | 205.1 ± 54.6 214.0 | 139.9 ± 42.4 129.0 | 0.0077* | 175.3 ± 50.0 152.0 | 189.7 ± 54.1 192.0 | 0.5506 | 166.8 ± 61.1 165.0 | 151.6 ± 58.9 141.0 | 0.3682 | 155.9 ± 61.4 152.0 | 187.4 ± 81.4 162.5 | |
Min.–Max. | 133.0‒301.0 | 85.0‒248.0 | 121.0‒270.0 | 123.0‒282.0 | 95.0‒303.0 | 85.0‒265.0 | 72.0‒308.0 | 123.0‒359.0 | 0.2892 | ||||
COL T | Mean ± SD Median | 217.0 ± 26.5 214.3 | 166.5 ± 33.4 163.0 | 0.0024* | 225.1 ± 57.1 212.5 | 160.9 ± 16.4 157.0 | 0.0031* | 204.4 ± 65.3 187.0 | 203.9 ± 51.4 186.0 | 0.9016 | 190.4 ± 51.7 186.0 | 184.0‒39.5 192.5 | |
Min.–Max. | 185.0‒273.0 | 93.0‒224.0 | 133.0‒345.0 | 143.0‒192.0 | 128.0‒320.0 | 127.0‒316.0 | 96.0‒316.0 | 131.0‒246.0 | 0.9446 | ||||
HDL | Mean ± SD Median | 44.3 ± 9.1 47.7 | 45.4 ± 10.2 44.0 | 0.9711 | 43.1 ± 9.9 41.0 | 47.6 ± 8.4 47.0 | 0.2629 | 46.4 ± 13.6 48.0 | 38.9 ± 9.8 39.0 | 0.1214 | 46.0 ± 9.2 45.0 | 41.2 ± 14.2 39.0 | |
Min.–Max. | 30.0‒56.0 | 30.0‒61.0 | 27.0‒62.0 | 37.0‒58.0 | 30.0‒75.0 | 23.0‒54.0 | 30.0‒61.0 | 21.0‒75.0 | 0.1396 | ||||
LDL | Mean ± SD Median | 135.9 ± 27.5 131.2 | 92.5 ± 33.5 92.6 | 0.0060* | 134.1 ± 57.6 133.2 | 73.5 ± 21.5 65.8 | 0.0125* | 125.9 ± 62.0 118.0 | 129.2 ± 45.2 117.0 | 0.6801 | 115.0 ± 45.1 111.0 | 89.2 ± 50.2 69.2 | |
Min.–Max. | 101.4‒177.0 | 29.4‒158.4 | 29.0‒227.0 | 52.8‒116.0 | 46.8‒218.0 | 65.6‒251.6 | 57.2‒215.6 | 30.0‒181.0 | 0.1307 | ||||
TRIG | Mean ± SD Median | 184.2 ± 89.5 167.0 | 164.8 ± 73.9 165.0 | 0.7172 | 234.1 ± 147.1 203.5 | 219.6 ± 102.3 216.0 | 0.9710 | 180.8 ± 112.3 146.0 | 178.9 ± 66.5 176.0 | 0.6303 | 176.1 ± 79.9 160.0 | 256.8 ± 136.9 213.5 | |
Min.–Max. | 77.0‒329.0 | 55.0‒327.0 | 56.0‒650.0 | 116.0‒398.0 | 67.0‒488.0 | 67.0‒297.0 | 72.0‒356.0 | 53.0‒484.0 | 0.1024 | ||||
CREA-S | Mean ± SD Median | 0.9 ± 0.3 0.8 | 0.9 ± 0.3 0.9 | 0.9718 | 0.8 ± 0.2 0.7 | 0.6 ± 0.1 0.6 | 0.0524 | 0.9 ± 0.4 0.8 | 0.9 ± 0.4 0.8 | 0.7695 | 0.9 ± 0.4 0.9 | 0.8 ± 0.2 0.7 | |
Min.–Max. | 0.6‒1.4 | 0.5‒1.7 | 0.4‒1.2 | 0.4‒0.8 | 0.5‒1.8 | 0.5‒2.2 | 0.5‒2.2 | 0.6‒1.3 | 0.5781 | ||||
M. ALB | Mean ± SD Median | 64.0 ± 70.8 41.5 | 17.9 ± 20.8 9.0 | 0.0647 | 60.5 ± 170.8 11.5 | 25.2 ± 27.4 16.2 | 0.5757 | 61.53 ± 119.8 24.0 | 70.0 ± 167.1 7.2 | 0.4638 | 90.1 ± 182.8 21.0 | 18.9 ± 25.6 5.8 | |
Min.–Max. | 1.0‒205.0 | 1.0‒67.0 | 1.0‒650.0 | 1.0‒76.0 | 1.0‒439.0 | 1.0‒525.0 | 1.0‒650.0 | 1.0 ± 84.7 | 0.1216 | ||||
CRP | Mean ± SD Median | 4.4 ± 3.7 3.8 | 3.1 ± 2.8 2.5 | 0.3929 | 4.1 ± 3.8 3.3 | 3.5 ± 2.2 4.2 | 0.8557 | 4.2 ± 4.1 1.9 | 3.7 ± 3.3 3.4 | 0.9016 | 3.3 ± 3.4 1.7 | 2.3 ± 2.2 1.9 | |
Min.–Max. | 0.6 ± 11.9 | 0.6 ± 9.5 | 0.4‒13.3 | 0.4‒6.9 | 0.3‒11.5 | 0.3‒11.7 | 0.3‒11.7 | 0.1‒8.0 | 0.5257 | ||||
AGP | Mean ± SD Median | 111.7 ± 67.4 95.0 | 87.4 ± 24.5 88.0 | 0.7573 | 86.6 ± 15.0 85.0 | 77.9 ± 15.3 73.0 | 0.2793 | 77.1 ± 12.5 72.0 | 83.8 ± 28.1 76.0 | 0.7063 | 73.0 ± 35.6 69.0 | 74.6 ± 22.3 74.0 | |
Min.–Max. | 72.0‒263.0 | 55.0‒140.0 | 59.0‒118.0 | 56.0‒102.0 | 60.0‒102.0 | 52.0‒172.0 | 4.0‒176.0 | 21.0‒111.0 | 0.5901 | ||||
TAC | Mean ± SD Median | 44.7 ± 20.2 51.0 | 59.4 ± 26.6 69.0 | 0.1223 | 38.8 ± 31.7 29.0 | 46.9 ± 27.7 51.0 | 0.6015 | 29.9 ± 28.4 22.0 | 25.9 ± 28.0 13.0 | 0.4636 | 21.9 ± 23.9 11.0 | 28.4 ± 20.9 17.5 | |
Min.–Max. | 8.0‒68.0 | 8.0‒94.0 | 9.0‒87.0 | 9.0‒87.0 | 6.0‒96.0 | 84.0‒13.0 | 2.0‒82.0 | 8.0‒60.0 | 0.1491 | ||||
MDA | Mean ± SD Median | 2.9 ± 1.4 3.7 | 4.0 ± 0.7 3.8 | 0.1922 | 3.7 ± 0.9 3.8 | 3.7 ± 0.5 3.6 | 0.7990 | 3.5 ± 1.1 3.9 | 3.4 ± 1.4 3.4 | 0.6603 | 3.5 ± 1.4 3.7 | 3.2 ± 1.3 3.4 | |
Min.–Max. | 1.1‒4.2 | 3.2‒5.1 | 2.3‒4.9 | 3.1‒4.3 | 1.4‒4.9 | 1.4‒6.3 | 1.0‒6.2 | 1.4‒5.3 | 0.5900 | ||||