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Table 6 Analysis of the relationship between the MTHFR methylation pattern and the A1298C + C677T polymorphism of MTHFR and biochemical, inflammatory and oxidative stress variables

From: The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

  Hypermethylated Partially methylated
677CC/1298AA (8) 677CC/1298AC (10) + CC (3) p 677CT (11) + TT (3)/1298AA (14) 677CT/1298AC (7) p 677CC/1298AA (13) 677CC/298AC (12) + CC (5) P 677CT (21) + TT (2)/1298AA (23) 677CT/1298AC (11) P
HbA1c Mean  ±  SD
Median
9.4 ± 2.0
9.2
7.9 ± 2.8
7.1
0.0638 8.0 ± 1.3
8.1
7.9 ± 1.2
7.5
0.7653 7.8 ± 1.5
7.8
8.6 ± 1.8
9.2
0.1547 8.0 ± 2.0
7.5
8.9 ± 1.8
8.6
 
Min.–Max. 6.4‒3.0 5.3‒14.4 5.7‒1.1 6.5‒9.6 4.1‒10.3 4.3‒11.0   4.7‒12.7 5.7‒11.2 0.1262
GLIC Mean  ±  SD
Median
205.1 ± 54.6
214.0
139.9 ± 42.4
129.0
0.0077* 175.3 ± 50.0
152.0
189.7 ± 54.1
192.0
0.5506 166.8 ± 61.1
165.0
151.6 ± 58.9
141.0
0.3682 155.9 ± 61.4
152.0
187.4 ± 81.4
162.5
 
Min.–Max. 133.0‒301.0 85.0‒248.0 121.0‒270.0 123.0‒282.0 95.0‒303.0 85.0‒265.0   72.0‒308.0 123.0‒359.0 0.2892
COL T Mean  ±  SD
Median
217.0 ±  26.5
214.3
166.5 ± 33.4
163.0
0.0024* 225.1 ± 57.1
212.5
160.9 ± 16.4
157.0
0.0031* 204.4 ± 65.3
187.0
203.9 ± 51.4
186.0
0.9016 190.4 ± 51.7
186.0
184.0‒39.5
192.5
 
Min.–Max. 185.0‒273.0 93.0‒224.0 133.0‒345.0 143.0‒192.0 128.0‒320.0 127.0‒316.0   96.0‒316.0 131.0‒246.0 0.9446
HDL Mean  ±  SD
Median
44.3 ± 9.1
47.7
45.4 ± 10.2
44.0
0.9711 43.1 ± 9.9
41.0
47.6 ± 8.4
47.0
0.2629 46.4 ± 13.6
48.0
38.9 ± 9.8
39.0
0.1214 46.0 ± 9.2
45.0
41.2 ± 14.2
39.0
 
Min.–Max. 30.0‒56.0 30.0‒61.0 27.0‒62.0 37.0‒58.0 30.0‒75.0 23.0‒54.0   30.0‒61.0 21.0‒75.0 0.1396
LDL Mean  ±  SD
Median
135.9 ± 27.5
131.2
92.5 ± 33.5
92.6
0.0060* 134.1 ± 57.6
133.2
73.5 ± 21.5
65.8
0.0125* 125.9 ± 62.0
118.0
129.2 ± 45.2
117.0
0.6801 115.0 ± 45.1
111.0
89.2 ± 50.2
69.2
 
Min.–Max. 101.4‒177.0 29.4‒158.4 29.0‒227.0 52.8‒116.0 46.8‒218.0 65.6‒251.6   57.2‒215.6 30.0‒181.0 0.1307
TRIG Mean  ±  SD
Median
184.2 ± 89.5
167.0
164.8 ± 73.9
165.0
0.7172 234.1 ± 147.1
203.5
219.6 ± 102.3
216.0
0.9710 180.8 ± 112.3
146.0
178.9 ± 66.5
176.0
0.6303 176.1 ± 79.9
160.0
256.8 ± 136.9
213.5
 
Min.–Max. 77.0‒329.0 55.0‒327.0 56.0‒650.0 116.0‒398.0 67.0‒488.0 67.0‒297.0   72.0‒356.0 53.0‒484.0 0.1024
CREA-S Mean  ±  SD
Median
0.9 ± 0.3
0.8
0.9 ± 0.3
0.9
0.9718 0.8 ± 0.2
0.7
0.6 ± 0.1
0.6
0.0524 0.9 ± 0.4
0.8
0.9 ± 0.4
0.8
0.7695 0.9 ± 0.4
0.9
0.8 ± 0.2
0.7
 
Min.–Max. 0.6‒1.4 0.5‒1.7 0.4‒1.2 0.4‒0.8 0.5‒1.8 0.5‒2.2   0.5‒2.2 0.6‒1.3 0.5781
M. ALB Mean  ±  SD
Median
64.0 ± 70.8
41.5
17.9 ± 20.8
9.0
0.0647 60.5 ± 170.8
11.5
25.2 ± 27.4
16.2
0.5757 61.53 ± 119.8
24.0
70.0 ± 167.1
7.2
0.4638 90.1 ± 182.8
21.0
18.9 ± 25.6
5.8
 
Min.–Max. 1.0‒205.0 1.0‒67.0 1.0‒650.0 1.0‒76.0 1.0‒439.0 1.0‒525.0   1.0‒650.0 1.0 ± 84.7 0.1216
CRP Mean  ±  SD
Median
4.4 ± 3.7
3.8
3.1 ± 2.8
2.5
0.3929 4.1 ± 3.8
3.3
3.5 ± 2.2
4.2
0.8557 4.2 ± 4.1
1.9
3.7 ± 3.3
3.4
0.9016 3.3 ± 3.4
1.7
2.3 ± 2.2
1.9
 
Min.–Max. 0.6 ± 11.9 0.6 ± 9.5 0.4‒13.3 0.4‒6.9 0.3‒11.5 0.3‒11.7   0.3‒11.7 0.1‒8.0 0.5257
AGP Mean  ±  SD
Median
111.7 ± 67.4
95.0
87.4 ± 24.5
88.0
0.7573 86.6 ±  15.0
85.0
77.9 ± 15.3
73.0
0.2793 77.1 ± 12.5
72.0
83.8 ± 28.1
76.0
0.7063 73.0 ± 35.6
69.0
74.6 ± 22.3
74.0
 
Min.–Max. 72.0‒263.0 55.0‒140.0 59.0‒118.0 56.0‒102.0 60.0‒102.0 52.0‒172.0   4.0‒176.0 21.0‒111.0 0.5901
TAC Mean  ±  SD
Median
44.7 ± 20.2
51.0
59.4 ± 26.6
69.0
0.1223 38.8 ± 31.7
29.0
46.9 ± 27.7
51.0
0.6015 29.9 ± 28.4
22.0
25.9 ± 28.0
13.0
0.4636 21.9 ± 23.9
11.0
28.4 ± 20.9
17.5
 
Min.–Max. 8.0‒68.0 8.0‒94.0 9.0‒87.0 9.0‒87.0 6.0‒96.0 84.0‒13.0   2.0‒82.0 8.0‒60.0 0.1491
MDA Mean ± SD
Median
2.9 ± 1.4
3.7
4.0 ± 0.7
3.8
0.1922 3.7 ± 0.9
3.8
3.7 ± 0.5
3.6
0.7990 3.5 ± 1.1
3.9
3.4 ± 1.4
3.4
0.6603 3.5 ± 1.4
3.7
3.2 ± 1.3
3.4
 
Min.–Max. 1.1‒4.2 3.2‒5.1 2.3‒4.9 3.1‒4.3 1.4‒4.9 1.4‒6.3   1.0‒6.2 1.4‒5.3 0.5900
  1. HbA1C (%) glycated haemoglobin, GLIC (mg/dL) fasting glycemia, TC (mg/dL) total cholesterol, HDL (mg/dL) high density lipoprotein, LDL (mg/dL) light density lipoprotein cholesterol, TRIG (mg/dL) triglycerides, CREA-S (mg/dL) serum creatinine, M. ALB (mg/dL) 24 h albumin excreted in the urine, RCP (mg/dL) reactive C protein, AGP (mg/dL) alpha 1 acid glycoprotein, TAC (%) total antioxidant capacity, MDA (µM) malondialdehyde
  2. * Statistically significant (p < 0.05), Mann–Whitney test