Anti-inflammatory effects of empagliflozin in patients with type 2 diabetes and insulin resistance

Table 3 Association between changes in log[hsCRP] and various parameters coefficients

	Estimate	Std. error	t value	P
∆ACR (mg/gCr)	0.0006272	0.0003121	2.01	0.0697
∆BMI	− 0.004537	0.01105	− 0.411	0.6892
∆DBP (mmHg)	− 0.002671	0.002109	− 1.266	0.2316
∆eGFR (ml/min/1.73m2)	0.0002273	0.002345	0.097	0.9246
∆γGTP (IU/L)	− 0.001513	0.001401	− 1.08	0.3031
∆AST (IU/L)	0.003259	0.001935	1.684	0.1203
∆ALT (IU/L)	− 0.003582	0.00151	− 2.372	0.037*
∆HbA1c (%)	0.04275	0.02592	1.65	0.1273
∆HDL-C (mg/dL)	− 0.002794	0.001159	− 2.411	0.0346*
∆HOMA-IR	0.06453	0.0254	2.541	0.0274*
∆LDL (mg/dL)	0.0008015	0.0008732	0.918	0.3784
∆RLPC (mg/dL)	0.06442	0.02548	2.528	0.0281*
∆SBP (mmHg)	− 0.002882	0.00124	− 2.324	0.0403*
∆TG (mg/dL)	0.000000518	0.0003293	0.002	0.9988

R2 = 0.9855, p-value = 4.709 × 10⁻⁸
Multiple linear regression analysis was used to test the association between change in log[hsCRP] and changes in various parameters across 12 months in EMPA group
hsCRP high sensitivity C-reactive protein, ACR albumin-to-creatinine ratio, BMI body mass index, eGFR estimated glomerular filtration rate, GTP, gamma-glutamyl transpeptidase, AST aspartate aminotransferase, ALT alanine aminotransferase, HbA1c hemoglobin A1c, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglyceride, RLP-C remnant-like particle cholesterol, SBP systolic blood pressure, DBP diastolic blood pressure
*p < 0.05

ISSN: 1758-5996