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Table 3 Negative binomial regressions for severe, non-severe, any, and nocturnal hypoglycemic events

From: Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil

  IRR (95% CI) p-value
Severe hypoglycemic eventsa
 Age (years) 0.98 (0.97–0.99) 0.001
 Gender: female [ref. male] 1.67 (1.01–2.77) 0.047
 Duration of diabetes (years) 1.03 (1.01–1.05) 0.001
 Fear of hypoglycemia (scale 1–10) 1.17 (1.06–1.29) 0.002
 Period: prospective [ref. retrospective] 4.75 (2.75–8.23) < 0.001
Non-severe hypoglycemic eventsa
 Duration of insulin therapy (years) 1.02 (1.01–1.03) 0.003
 Diabetes type: T1DM [ref. T2DM] 2.59 (1.99–3.38) < 0.001
 Frequency of blood glucose monitoring (days) 1.14 (1.07–1.20) < 0.001
 Period: prospective [ref. retrospective] 1.81 (1.53–2.14) < 0.001
Any hypoglycemic eventsa
 Duration of insulin therapy (years) 1.02 (1.01–1.03) < 0.001
 Diabetes type: T1DM [ref. T2DM] 2.34 (1.81–3.03) < 0.001
 Frequency of blood glucose monitoring (days) 1.13 (1.06–1.20) < 0.001
 Period: prospective [ref. retrospective] 2.05 (1.76–2.39) < 0.001
Nocturnal hypoglycemic eventsa
 Diabetes type: T1DM [ref. T2DM] 2.06 (1.46–2.90) < 0.001
 Frequency of blood glucose monitoring (days) 1.12 (1.05–1.20) 0.001
 Hypoglycemia awareness: impaired or severely impaired [ref. normal] 0.65 (0.46–0.91) 0.012
  1. Negative binomial regression model (after stepwise) Subject effect: Patient; Within-subject effect: Period; Offset variable: Ln (follow-up time); Dependent variable: number of hypoglycemic events. Independent variables: age, gender, HbA1c, diabetes type, duration of diabetes, duration of insulin therapy, type of insulin therapy, frequency of blood glucose monitoring, knowledge of hypoglycemia, hypoglycemia unawareness, fear of hypoglycemia and period
  2. IRR incidence rate ratio, CI confidence interval. Ref. reference category versus the one is making comparison (categorical variables); for continuous variables, please consider IRR per additional unit