Fig. 1

Interaction between risk scores and MetS severity score by disease risk score quintiles. Hazard ratios (HR) or odds ratios (OR) for each MetS severity score Z-score standard deviation unit by quintiles of risk score for cardiovascular disease (CVD) (a Framingham risk score; b ASCVD score) and Type 2 diabetes mellitus (T2DM) (c Bang score (Ref. [5]); d Schmidt score (Ref. [4])). For each of the comparator risk scores, there was a significant interaction between MetS severity and future disease risk depending on the quintile of the comparator score, with increasing MetS severity exhibiting higher hazard ratios (HR) for future CHD among individuals in the lowest quintile of CVD risk according to the Framingham and ASCVD risk and with increasing MetS severity exhibiting higher HR’s for future diabetes among individuals in the middle quintiles of diabetes risk according to the Bang and Schmidt risk scores. All models controlled for study site