Association of mean platelet volume with incident type 2 diabetes mellitus risk: the Dongfeng–Tongji cohort study

Table 2 Multivariate adjusted hazard ratios with 95% CI for T2DM incidence

	MPV (fL)				P trend*
	Q1	Q2	Q3	Q4	P trend*
MPV	< 7.49	7.49–8.43	8.43–9.69	≥ 9.69
Median of MPV	6.90	7.95	8.99	10.7
Cases, n (person-years)	231 (15,301.77)	242 (15,059.60)	272 (15,194.28)	252 (15,206.09)
Model 1	Ref	1.24 (1.04, 1.49)	1.02 (0.88, 1.22)	1.17 (0.98, 1.39)	0.320
Model 2	Ref	1.37 (1.08, 1.63)	1.07 (0.86, 1.32)	1.25 (0.99, 1.58)	0.252
Model 3	Ref	1.39 (1.11, 1.75)	1.14 (0.90, 1.44)	1.39 (1.07, 1.81)	0.085
Sensitivity analysis
Excluding participants who developed diabetes during the first 2 years of follow-up^a	Ref	1.44 (1.13, 1.84)	1.16 (0.90, 1.49)	1.51 (1.14, 1.99)	0.028
Further adjustment for FBG at baseline	Ref	1.39 (1.10, 1.74)	1.10 (0.87, 1.39)	1.33 (1.02, 1.73)	0.193

Model 1: adjusted for age, sex
Model 2: additionally adjusted for BMI, smoking status, drinking status, education, physical activity, hypertension, hyperlipidemia, family history of DM, and examination center
Model 3: additionally adjusted for WBC and PLT
^a Sensitivity analysis was performed by excluding the newly diagnosed incident diabetes patients during the first 2 years of follow-up (n = 249)
* P value when assigning the median value to each quartile and entered as a continuous variable in the models

ISSN: 1758-5996