Table 6 Clinical parameters
Parameters | Baseline | Week 14 | Change | P value |
|---|---|---|---|---|
HbA1c (NGSP, %) | 7.8 ± 0.7 (184) | 7.3 ± 0.8 (181) | − 0.6 ± 0.7 (178) | < 0.001 |
HbA1c (mmol/mol) | 62.1 ± 7.5 (184) | 55.9 ± 8.7 (181) | − 6.2 ± 7.5 (178) | < 0.001 |
Fasting plasma glucose (mg/dl) | 156.2 ± 39.6 (136) | 137.2 ± 29.9 (147) | − 18.5 ± 39.5 (126) | < 0.001 |
Body weight (kg) | 82.5 ± 14.6 (175) | 80.7 ± 14.8 (173) | − 2.3 ± 2.8 (160) | < 0.001 |
BMI (kg/m2) | 30.0 ± 4.4 (175) | 29.3 ± 4.4 (172) | − 0.8 ± 1.0 (160) | < 0.001 |
Abdominal circumference (cm) | 100.0 ± 11.6 (184) | 98.3 ± 11.1 (178) | − 1.7 ± 4.5 (175) | < 0.001 |
Body fat percentage (%) | 33.5 ± 7.7 (172) | 33.7 ± 7.9 (172) | − 0.4 ± 2.4 (156) | 0.06 |
Body fat (kg) | 27.8 ± 8.8 (172) | 27.4 ± 9.1 (171) | − 1.0 ± 2.7 (156) | < 0.001 |
Lean body mass (kg) | 54.8 ± 10.9 (172) | 53.3 ± 10.8 (171) | − 1.3 ± 2.3 (156) | < 0.001 |
Muscle mass (kg) | 51.8 ± 10.4 (172) | 50.5 ± 10.3 (172) | − 1.2 ± 2.2 (156) | < 0.001 |
Body water (kg) | 36.7 ± 6.3 (172) | 35.8 ± 6.4 (172) | − 0.8 ± 1.9 (156) | < 0.001 |
Bone mass (kg) | 3.0 ± 0.5 (172) | 2.9 ± 0.5 (171) | − 0.1 ± 0.2 (156) | < 0.001 |
Basal metabolic rate (kcal) | 1585.8 ± 296.2 (172) | 1543.2 ± 292.4 (171) | − 41.5 ± 73.0 (156) | < 0.001 |
TC (mg/dl) | 184.9 ± 33.1 (146) | 185.9 ± 32.0 (158) | − 0.1 ± 24.9 (141) | 0.94 |
HDL-C (mg/dl) | 47.1 ± 11.1 (166) | 47.9 ± 10.9 (169) | 0.9 ± 6.3 (158) | 0.08 |
LDL-C (mg/dl) | 108.3 ± 29.8 (129) | 108.5 ± 27.1 (141) | − 1.1 ± 22.0 (118) | 0.59 |
TG (mg/dl) | 135.0 [99.0, 178.0] (133) | 127.0 [93.0, 174.0] (145) | 0.0 [− 30.0, 21.0] (123) | 0.35 |
AST (IU/l) | 32.5 ± 18.4 (171) | 27.4 ± 14.0 (167) | − 5.1 ± 12.9 (160) | < 0.001 |
ALT (IU/l) | 46.0 ± 30.4 (171) | 37.6 ± 26.2 (167) | − 8.4 ± 19.2 (161) | < 0.001 |
γGTP (IU/l) | 43.0 [29.0, 69.0] (157) | 33.0 [24.0, 56.0] (153) | − 6.0 [− 18.0, 0.0] (147) | < 0.001 |
Serum creatinine (mg/dl) | 0.72 ± 0.19 (173) | 0.75 ± 0.20 (168) | 0.02 ± 0.09 (162) | 0.001 |
Uric acid (mg/dl) | 5.5 ± 1.5 (169) | 5.1 ± 1.3 (174) | − 0.4 ± 0.8(162) | < 0.001 |
Amylase (IU/l) | 62.2 ± 33.0 (116) | 66.6 ± 33.8 (120) | 3.3 ± 16.4 (104) | 0.040 |
RBC (× 104/μl) | 487.0 ± 47.5 (160) | 509.5 ± 45.6 (161) | 23.0 ± 25.3 (151) | < 0.001 |
WBC (/μl) | 7211.7 ± 1760.1 (160) | 7174.3 ± 1856.8 (161) | 27.5 ± 1369.5 (151) | 0.81 |
Hemoglobin (g/dl) | 14.5 ± 1.6 (160) | 15.1 ± 1.6 (161) | 0.6 ± 0.8 (151) | < 0.001 |
Hematocrit (%) | 43.5 ± 4.2 (160) | 45.8 ± 4.5 (161) | 2.4 ± 2.6 (151) | < 0.001 |
Platelet (× 104/μl) | 24.3 ± 6.5 (160) | 24.4 ± 6.4 (161) | 0.1 ± 3.2 (151) | 0.76 |
Urinary albumin/Cr (mg/g Cr) | 14.9 [7.8, 32.4] (105) | 16.0 [7.7, 34.5] (110) | 0.3 [− 5.5, 7.0] (85) | 0.64 |
Urinary albumin (mg/l) | 16.6 [4.6, 47.6] (50) | 13.3 [7.0, 39.6] (60) | − 2.2 [− 12.4, 0.7] (41) | 0.07 |
Urinary creatinine (mg/dl) | 129.0 ± 73.7 (48) | 89.8 ± 47.3 (63) | − 33.2 ± 76.3 (42) | 0.007 |
Systolic blood pressure (mmHg) | 132.3 ± 14.1 (183) | 129.8 ± 14.5 (181) | − 2.7 ± 13.7 (178) | 0.011 |
Diastolic blood pressure (mmHg) | 80.6 ± 11.9 (183) | 79.0 ± 12.2 (181) | − 1.6 ± 10.4 (178) | 0.047 |