Skip to main content

Advertisement

Table 2 The comparisons of metabolic manifestations in different porcine strains and dietary interventions

From: Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs

Strain Age Intervention Body weight (kg) Fasting glucose level Fasting insulin level Features Refs.
Diet Time
Lee-Sung 2 years High fat high fructose 12 months Con: 98 Int: 153 (1.6 ×)a Con: 3.9 mM Int: 4.4 mM (1.1 ×) Con: 2.0 μIU/ml Int: 6.9 μIU/ml (3.5 ×) Hyperinsulinemia, dyslipidemia, insulin resistance, intense insulin secretion (IVGTT) Current
Ossabaw 5–10 months High fat high fructoseb 6 months Con: 56 Int: 87 (1.6 ×) Con: 77 mg/dl Int: 87 mg/dl (1.1 ×) Con: 10 Int: 18 (1.8 ×) Slight hyperinsulinemia, severe dyslipidemia, insulin resistance [14]
Ossabaw 6 months High fat high fructoseb 6 months Con: 54 Int: 91 (1.7 ×) Con: 73 mg/dl Int: 80 mg/dl (1.1 ×) Con: 5 μIU/ml Int: 21 μIU/ml (4.2 ×) Hyperinsulinemia, severe dyslipidemia, insulin resistance [39]
Göttingen 7–8 months High fat high energy 3 months Con: 24 Int: 32 (1.3 ×) Con: 3.6 mM Int: 4.3 mM (1.2 ×) Con: 23 pM Int: 80 pM (3.5 ×) Hyperinsulinemia, slightly increasing insulin secretion (IVGTT) [37]
Göttingen 7 weeks High fat high sucrose 4 months Con: ~ 14 Int: ~ 17 (1.2 ×) Con: 4.2 mM Int: 4.7 mM (1.1 ×) Con: 34 pM Int: 47 pM (1.4 ×) Slight hyperinsulinemia, dyslipidemia, slightly increasing insulin secretion (IVGTT) [38]
Yucatan 3 months High fat high fructose 7 months Con: 40 Int: 73 (1.8 ×) Con: ~ 2.3 mMb Int: ~ 2.8 mMc (1.2 ×) Con: ~ 1.5 μIU/mlc Int: ~ 5 μIU/mlc (3.3 ×) Hyperinsulinemia, dyslipidemia, insulin resistance, intense insulin secretion (IVGTT) [40]
Bama 6 months High fat high sucrose 23 months Con: 51 Int: 140 (2.7 ×) Con: 6.62 mM Int: 4.99 mM (0.8 ×) Con: 5.7 μIU/ml Int: 28.3 μIU/ml (5 ×) Hyperinsulinemia, dyslipidemia, insulin resistance [41]
  1. Con control diet group, Int intervention diet group
  2. aThe number in parentheses is the fold value between two groups
  3. bSupplied with additional cholesterol and sodium cholate
  4. cThe value is estimated from dot graph