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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

Fig. 3

Expression of TLR2 in the STZ-induced type 1 diabetic mouse glomeruli. HE staining (upper lane), immunostaining for TLR2 (green, middle lane), and merged (lower lane) immunostaining for TLR2 (green) and podoplanin (red), with DAPI staining of nuclei (blue). The TLR2 expression locates between podocytes immunostained by anti-podoplanin. Little expression of TLR2 is observed in the non-diabetic ICR mice (ICR) and non-diabetic ICR mice administered Pg-LPS (LPS), but TLR2 is observed in the STZ-induced type 1 diabetic mouse glomeruli. The expression level of TLR2 was higher in the diabetic mice administered Pg-LPS (STZ-LPS) and the level slightly lower in the diabetic mice administered both Pg-LPS and eritoran (eritoran). Bars: 20 μm

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