| |
Normoalbuminuria
|
Albuminuria
|
P value
|
|---|
|
NAPCR < 120 mg/g
|
NAPCR ≥ 120 mg/g
|
NAPCR < 120 mg/g
|
NAPCR ≥ 120 mg/g
|
|---|
|
(n = 146)
|
(n = 57)
|
(n = 40)
|
(n = 82)
|
|---|
|
Sex, male (%)
|
57 (39.0)
|
17 (29.8)
|
20 (50.0)
|
32 (39.0)
|
0.256
|
|
Age, years
|
54.7 ± 11.4
|
56.5 ± 9.8
|
59.7 ± 9.1
|
54.3 ± 12.0
|
0.021
|
|
BMI, kg/m2
|
25.0 ± 3.6
|
24.0 ± 2.7
|
24.3 ± 2.9
|
24.1 ± 3.9
|
0.246
|
|
Duration of diabetes, years
|
6.8 ± 5.7
|
8.1 ± 6.7
|
9.4 ± 6.1
|
8.5 ± 7.7
|
0.059
|
|
Hypertension, yes
|
52 (35.6)
|
29 (50.9)
|
22 (55.0)
|
35 (42.7)
|
0.071
|
|
SBP, mmHg
|
123 ± 14
|
123 ± 14
|
124 ± 15
|
125 ± 14
|
0.682
|
|
DBP, mmHg
|
75 ± 10
|
74 ± 9
|
73 ± 12
|
75 ± 10
|
0.713
|
|
HbA1c, %
|
7.1 ± 1.3
|
7.6 ± 1.6
|
7.3 ± 1.4
|
8.0 ± 1.5
|
<0.001
|
|
Total cholesterol, mg/dL
|
181 ± 38
|
184 ± 50
|
170 ± 44
|
179 ± 42
|
0.463
|
|
LDL cholesterol, mg/dL
|
101 ± 31
|
103 ± 44
|
91 ± 35
|
97 ± 33
|
0.356
|
|
HDL cholesterol, mg/dL
|
48 ± 13
|
48 ± 13
|
44 ± 11
|
48 ± 14
|
0.252
|
|
Triglycerides, mg/dL
|
137 (89–183)
|
122 (85–188)
|
128 (93–197)
|
150 (106–214)
|
0.321
|
|
Serum creatinine, mg/dL
|
0.86 ± 0.17
|
0.80 ± 0.16
|
0.88 ± 0.25
|
0.97 ± 0.33
|
0.001
|
|
eGFR, mL/min/1.73 m2
|
87.6 ± 16.7
|
89.0 ± 14.9
|
84.0 ± 18.1
|
79.9 ± 23.1
|
0.027
|
|
ACR, mg/g
|
9.6 (6.0–14.8)
|
12.3 (6.7–17.2)
|
40.7 (37.1–74.7)
|
131.5 (51.1–499.0)
|
<0.001
|
|
NAPCR, mg/g
|
75.1 (57.8–91.9)
|
143.0 (131.4–173.6)
|
88.0 (65.6–106.0)
|
203.8 (151.9–295.2)
|
<0.001
|
|
PCR, mg/g
|
85.7 (67.0–104.9)
|
153.6 (144.2–190.4)
|
137.5 (116.5–159.9)
|
346.9 (213.3–788.4)
|
<0.001
|
|
Diabetic retinopathy, n (%)
|
18 (19.4)
|
10 (25.0)
|
14 (51.9)
|
34 (55.7)
|
<0.001
|
|
Lipid-lowering agent, n (%)
|
86 (58.9)
|
27 (47.4)
|
23 (57.5)
|
49 (59.8)
|
0.452
|
|
RAS inhibitor, n (%)
|
56 (38.4)
|
25 (43.9)
|
25 (62.5)
|
59 (72.0)
|
<0.001
|
- Data are mean ± standard deviation, medians (interquartile range) for continuous variables and frequencies (percentage) for categorical variables
-
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c glycated hemoglobin, LDL low-density lipoprotein, HDL high-density lipoprotein, eGFR estimated glomerular filtration rate, ACR albumin-to-creatinine ratio, NAPCR nonalbumin protein-to-creatinine ratio
