Skip to main content

Table 4 Characteristics and complications for the first and last visit of the young-onset T2DM cohort

From: Characteristics and cardiovascular complications of a large cohort of adults diagnosed with type 2 diabetes <45 years

   First contact
N = 886
Last contact
N = 886
p value
Mean age at contacts   48.9 ± 11.5 57.3 ± 12.5 <0.0001
Mean diabetes duration (years)   12.1 ± 10.7 20.5 ± 11.8 <0.0001
Mean HbA1c % (mmol/mol)   7.9 ± 1.7 (62 ± 19) 7.3 ± 1.3 (56 ± 14) <0.0001
 % HbA1c ≥7% (52 mmol/mol)   66 54.5 <0.0001
 % Statin   32.2 75.7 <0.0001
Number of antihypertensive medications     <0.0001
 0   44.9% 23.1%  
 1   21.7% 17.0%  
 2   17.7% 20.0%  
 ≥3   15.8% 39.7%  
% MF   30.9 54.2 <0.0001
% SU   5.5 1.6 <0.0001
% MF + SU   20.0 12.9 <0.0001
% DPP-4   1.7 3.5 0.014
% GLP-1   1.2 8.4 <0.0001
% Insulin   36.9 81.9 <0.0001
% On 1 injection of insulin   7.4 5.4 0.054
% On 2 or 3 injections of insulin   12.5 6.9 <0.0001
% On multiple injections of insulin   16.9 69.6 <0.0001
Mean BMI (kg/m2)   31.7 ± 5.8 31.2 ± 5.8 0.009
 % Hypertension   55.6 49.9 0.018
Mean TG   192.5 ± 217.2 152.0 ± 144.4 <0.0001
Mean LDL   107.3 ± 37.4 77.9 ± 31.1 <0.0001
 % LDL not on target in primary CV prevention   58.3 27.7 <0.0001
 % LDL not on target in secondary CV prevention   78.7 44.8 <0.0001
 % Smoking   17.2 16.6 0.709
 % ≥2 CV risk factors   87.6 81.7 <0.0001
 % DRP   27.2 40.2 <0.0001
 % Microalbuminuria   28.1 34.4 0.003
 % Carotid surgery   0.7 (6) 0.9 (8) 0.500
 % Surgery lower limbs   3.7 (33) 6.9 (61) <0.0001
 % TIA/CVA   3.6 (32) 7.2 (64) <0.0001
 % Cardiac event   12.8 (113) 20.1 (178) <0.0001
 % CV event (peripheral; heart)   21.6 (191) 37.8 (335) <0.0001
 % New surgery lower limbs 2.6 (23)    
 % New TIA/CVA 1.0 (9)    
 % New cardiovascular event 4.1 (36)    
  1. Data are mean ± SD, % or (number)
  2. p values highlighted in italic are considered significant
  3. MF metformin with or without insulin; SU sulfonylureum with or without insulin; DPP-4 DPP-4-inhibitor; GLP-1 GLP-1-receptor-agonist; BMI body mass index; TG triglycerides; LDL LDL-cholesterol; CV cardiovascular; DRP diabetic retinopathy; TIA transient ischemic attack; CVA cerebrovascular accident; cardiac event a myocardial infarction or an intervention such as a percutaneous transluminal coronary angioplasty or a coronary artery bypass graft