Table 4 Characteristics and complications for the first and last visit of the young-onset T2DM cohort
First contact N = 886 | Last contact N = 886 | p value | ||
|---|---|---|---|---|
Mean age at contacts | 48.9 ± 11.5 | 57.3 ± 12.5 | <0.0001 | |
Mean diabetes duration (years) | 12.1 ± 10.7 | 20.5 ± 11.8 | <0.0001 | |
Mean HbA1c % (mmol/mol) | 7.9 ± 1.7 (62 ± 19) | 7.3 ± 1.3 (56 ± 14) | <0.0001 | |
% HbA1c ≥7% (52 mmol/mol) | 66 | 54.5 | <0.0001 | |
% Statin | 32.2 | 75.7 | <0.0001 | |
Number of antihypertensive medications | <0.0001 | |||
0 | 44.9% | 23.1% | ||
1 | 21.7% | 17.0% | ||
2 | 17.7% | 20.0% | ||
≥3 | 15.8% | 39.7% | ||
% MF | 30.9 | 54.2 | <0.0001 | |
% SU | 5.5 | 1.6 | <0.0001 | |
% MF + SU | 20.0 | 12.9 | <0.0001 | |
% DPP-4 | 1.7 | 3.5 | 0.014 | |
% GLP-1 | 1.2 | 8.4 | <0.0001 | |
% Insulin | 36.9 | 81.9 | <0.0001 | |
% On 1 injection of insulin | 7.4 | 5.4 | 0.054 | |
% On 2 or 3 injections of insulin | 12.5 | 6.9 | <0.0001 | |
% On multiple injections of insulin | 16.9 | 69.6 | <0.0001 | |
Mean BMI (kg/m2) | 31.7 ± 5.8 | 31.2 ± 5.8 | 0.009 | |
% Hypertension | 55.6 | 49.9 | 0.018 | |
Mean TG | 192.5 ± 217.2 | 152.0 ± 144.4 | <0.0001 | |
Mean LDL | 107.3 ± 37.4 | 77.9 ± 31.1 | <0.0001 | |
% LDL not on target in primary CV prevention | 58.3 | 27.7 | <0.0001 | |
% LDL not on target in secondary CV prevention | 78.7 | 44.8 | <0.0001 | |
% Smoking | 17.2 | 16.6 | 0.709 | |
% ≥2 CV risk factors | 87.6 | 81.7 | <0.0001 | |
% DRP | 27.2 | 40.2 | <0.0001 | |
% Microalbuminuria | 28.1 | 34.4 | 0.003 | |
% Carotid surgery | 0.7 (6) | 0.9 (8) | 0.500 | |
% Surgery lower limbs | 3.7 (33) | 6.9 (61) | <0.0001 | |
% TIA/CVA | 3.6 (32) | 7.2 (64) | <0.0001 | |
% Cardiac event | 12.8 (113) | 20.1 (178) | <0.0001 | |
% CV event (peripheral; heart) | 21.6 (191) | 37.8 (335) | <0.0001 | |
% New surgery lower limbs | 2.6 (23) | |||
% New TIA/CVA | 1.0 (9) | |||
% New cardiovascular event | 4.1 (36) |