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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass

Fig. 2

Mammalian DNA demethylation process (modified from [19]). Cytosine may be methylated by DNMTs and affect gene transcription. In the process of demethylation, the methylated product 5mC can be actively reversed by TET proteins and TDG, thereby reverting to the cytosine form. Intermediate products include 5hmC, 5FC, and 5caC. Amount of 5hmC reflects DNA demethylation status

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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