| Control (n = 6) | Vehicle (n = 6) | Lina 10 mg/Kg (n = 6) | Empa 10 mg/Kg (n = 6) | Lina + empa (n = 6) |
---|---|---|---|---|---|
Body weight (g) | |||||
 Day 0 | 22.6 ± 0.2 | 20.0 ± 0.9 | 19.9 ± 0.9 | 20.3 ± 1.2 | 20.5 ± 1.0 |
 Day 21 | 25.1 ± 0.5 | 21.9 ± 0.7 | 21.6 ± 0.9* | 21.8 ± 1.2 | 22.8 ± 0.6 |
Plasma glucose (mg/dl) | 184.5 ± 14.1 | 470.7 ± 53.7†| 479.0 ± 49.2†| 319.3 ± 35.1 | 345.0 ± 57.6 |
GA (%) | 2.35 ± 0.36 | 5.86 ± 0.73* | 5.53 ± 0.43* | 2.58 ± 0.50§, # | 3.32 ± 0.44 |
ALT (U/l) | 28.3 ± 3.7 | 42.8 ± 5.7 | 52.5 ± 15.9 | 20.7 ± 4.0§ | 23.8 ± 2.3 |
Triglyceride (mg/dl) | 40.8 ± 5.3 | 36.8 ± 7.8 | 37.3 ± 7.3 | 26.0 ± 6.3 | 43.2 ± 8.4 |
Free fatty acid (mEq/l) | 0.76 ± 0.06 | 1.72 ± 0.15†| 1.80 ± 0.29†| 2.02 ± 0.21‡ | 2.10 ± 0.06‡ |
Insulin (ng/ml) | 0.53 ± 0.05 | 0.40 ± 0.07 | 0.69 ± 0.19 | 0.79 ± 0.06 | 0.92 ± 0.18§ |