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Table 3 Sensitivities and specificities around 95, 97.5 and 100 % for diagnosing GDM with corresponding cut-offs for HbA1c and probabilities for GDM estimated by logistic regression models

From: Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women

Outcome HbA1c alonea Model
Cut-off, HbA1c ≥ (%) Sensitivity (%) Specificity (%) Percentage of women avoiding OGTT Percentage of women avoiding OGTT misclassified Cut-off, probability of GDM ≥ Sensitivity (%) Specificity (%) Percentage of women avoiding OGTT Percentage of women avoiding OGTT misclassified
GDM-WHO week 32–36 4.7 100 3.7 3.4 0 0.009 100 8.5 8.0 0
4.8 97.3 8.0 7.7 2.0 0.011 97.3 11.2 10.7 1.5
4.9 91.9 17.1 16.6 2.8 0.013 94.6 14.3 13.8 2.3
5.5 29.7 95.0 6.4 73.2 0.16 29.7 95.0 6.4 73.2
5.6 21.6 97.7 3.4 63.3 0.22 21.6 97.7 3.4 63.3
5.9 0 100 0 0 0.50 0 100 0 0
GDM-WHO throughout pregnancy 4.4 100 0.5 0.5 0 0.018 100 2.9 2.7 0
4.5 97.6 2.4 2.4 6.7 0.026 97.6 11.2 10.6 1.5
4.6 95.2 7.7 7.5 4.3 0.027 95.2 11.8 11.3 2.8
5.2 14.3 95.2 5.4 82.4 0.15 19.1 95.1 5.9 78.4
5.3 9.5 97.8 2.7 76.4 0.18 16.7 97.4 3.5 68.6
5.8 0 100 0 0 0.37 2.4 100 0.2 0
GDM-IADPSG week 18–22b 4.7 100 16.6 16.2 0 0.010 100 16.0 15.7 0
4.8 87.5 30.3 29.8 1.0 0.0153 93.8 36.0 35.3 0.4
4.9 68.8 51.3 50.8 1.5 0.0154 87.5 36.5 35.9 0.8
5.2 12.5 94.7 5.5 94.6 0.056 18.8 95.0 5.3 91.7
5.3 6.3 97.4 2.7 94.5 0.067 0 97.4 2.5 100
5.8 0 100 0 0 0.18 0 100 0 0
GDM-IADPSG week 32–36b 4.6 100 1.0 1.0 0 0.003 100 2.0 1.9 0
5.0 96.6 31.4 30.1 0.5 0.013 96.6 23.9 23.0 0.7
5.1 82.8 48.2 46.7 1.7 0.018 93.1 36.0 34.6 0.9
5.5 31.0 94.7 6.5 77.9 0.13 37.9 95.0 6.5 73.2
5.6 20.7 97.5 3.3 71.4 0.18 24.1 97.5 3.5 68.2
5.8 6.9 100 0.3 0 0.57 3.5 100 0.2 0
GDM-IADPSG throughout pregnancyb 4.4 100 0.5 0.5 0 0.014 100 3.3 3.0 0
4.6 97.8 2.4 2.4 6.6 0.027 97.8 16.6 15.6 1.0
4.7 95.6 16.5 15.6 2.0 0.037 95.6 30.0 28.2 1.1
5.2 13.3 95.2 5.4 82.3 0.18 26.7 95.0 3.2 75.2
5.3 8.9 97.8 2.7 76.2 0.21 11.1 97.4 6.5 70.7
5.8 0 100 0 0 0.52 0 100 0 0
  1. See Table 2 for variables included in the various models. In addition, the percentage of women avoiding an OGTT by using cut-offs with high specificity to rule-in and high sensitivity to rule-out GDM and the percentage of those avoiding OGTT who are misclassified are shown
  2. aHbA1c at gestational week 18–22 was used for GDM-WHO throughout pregnancy, GDM-IADPSG at week 18–22 and GDM-IADPSG throughout pregnancy, while HbA1c at gestational week 32–36 was used for GDM-WHO at week 32–36 and GDM-IADPSG at week 32–36
  3. bModified IADPSG criteria were used, i.e. 1-h s-glucose was missing