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Table 2 Serum adrenal hormones, endothelial, and inflammatory markers in control, obese patients with NT, pre-HT & HT

From: Association of cardiac NT pro-β-type natriuretic peptide with metabolic and endothelial risk factors in young obese hypertensive patients: a perspective on the hypothalamic pituitary adrenal axis activation

 

Control-subjects (N = 30)

Obese patients

 

NT (N = 20)

Pre-HT (N = 20)

HT (N = 20)

Adrenal hormones

Cortisol (µg/dL)

9.1 ± 1.4

5.6 ± 0.7*

8.9 ± 2.4*, #

12.7 ± 0.5*, #, a

Aldosterone(µg/dL)

88.6 ± 8.5

132.1 ± 6.9*

195.9 ± 70.9*, #

320.2 ± 22.4*,#, a

ACTH(pg/ml)

23.8 ± 2.9

24.8 ± 5.6

79.6 ± 42.07*, #

44.2 ± 7.5*, #, a

NT-pro BNP(pg/ml)

73.07 ± 11.05

377.3 ± 87.8*

585.7 ± 155.7*, #

881.1 ± 130.9*, # a

Cytokine markers

  

TNF-α (ng/ml)

2.3 ± 0.5

6.02 ± 1.4*

14.3 ± 7.6*, #

31.6 ± 6.7*, #, a

IL-6 (ng/ml)

1.2 ± 0.2

5.1 ± 1.2*

9.3 ± 4.6*, #

18.5 ± 2.4*, #, a

IL-23 (ng/ml)

16.1 ± 3.1

76.9 ± 6.3*

93.5 ± 15.5*, #

186.6 ± 23.5*, #, a

hs-CRP (mg/L)

0.3 ± 0.09

0.9 ± 0.12*

1.8 ± 0.9*, #

3.7 ± 0.8*, #, a

  1. Values are mean ± SD for control healthy, obese normotensive, prehypertensive and hypertensive patients groups
  2. Values (*) is significantly different from control group; (#) significantly different from normotensive obese patients, (a) significantly different from prehypertensive obese patients. Values are statistically significant at P < 0.05 using one way ANOVA with LSD as post hoc test. (SPSS program)