DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Table 3 Effect of sitagiliptin on oxidative stress parameters in heart and kidney of 2K1C rats

Parameter	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	p values
Parameter	Sham	Sham + Sitagliptin	2K1C	2K1C + Sitagliptin	2K1C	Treatment	Interaction
Heart
MDA (nmol/mL)	47.62 ± 1.76	50.38 ± 3.41	77.08 ± 4.88	61.46 ± 4.06	<0.0001	0.1912	0.0087
NO (nmol/mL)	13.08 ± 2.52	9.66 ± 0.42	25.21 ± 2.81	21.86 ± 3.67	0.0002	0.2145	0.9896
APOP (ng/mL)	227.30 ± 32.31	230.48 ± 12.34	237.62 ± 22.28	232.86 ± 36.91	0.8246	0.9780	0.8897
CATALASE (U/L)	7.64 ± 0.31	7.40 ± 0.73	5.48 ± 0.54	7.08 ± 0.60	0.0482	0.2613	0.1338
MPO Activity (U/mg protein)	2.20 ± 0.09	1.90 ± 0.18	3.77 ± 0.17	2.30 ± 0.17	<0.0001	<0.0001	0.0013
Kidney
MDA (nmol/mL)	101.38 ± 7.84	124.92 ± 6.92	183.00 ± 10.77	133.51 ± 9.85	0.0001	0.1820	0.0010
NO (nmol/mL)	13.89 ± 1.28	11.21 ± 1.81	62.36 ± 5.49	52.59 ± 1.93	<0.0001	0.0594	0.2684
APOP (ng/mL)	391.90 ± 40.11	421.75 ± 24.02	978.57 ± 100.73	348.73 ± 35.44	<0.0001	<0.0001	<0.0001
CATALASE (U/L)	12.72 ± 1.20	10.50 ± 1.50	6.70 ± 0.38	11.08 ± 1.04	0.0234	0.3416	0.0075
MPO Activity (U/mg protein)	1.94 ± 0.28	1.79 ± 0.18	2.80 ± 0.22	1.85 ± 0.09	0.0359	0.0141	0.0646

Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
APOP advanced protein oxidation product, expressed as nmol/mL equivalent to Chloramine-T
Values are considered significance at p < 0.05

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