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Table 3 Effect of sitagiliptin on oxidative stress parameters in heart and kidney of 2K1C rats

From: DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats

Parameter Sham Sham + Sitagliptin 2K1C 2K1C + Sitagliptin p values
2K1C Treatment Interaction
Heart
 MDA (nmol/mL) 47.62 ± 1.76 50.38 ± 3.41 77.08 ± 4.88 61.46 ± 4.06 <0.0001 0.1912 0.0087
 NO (nmol/mL) 13.08 ± 2.52 9.66 ± 0.42 25.21 ± 2.81 21.86 ± 3.67 0.0002 0.2145 0.9896
 APOP (ng/mL) 227.30 ± 32.31 230.48 ± 12.34 237.62 ± 22.28 232.86 ± 36.91 0.8246 0.9780 0.8897
 CATALASE (U/L) 7.64 ± 0.31 7.40 ± 0.73 5.48 ± 0.54 7.08 ± 0.60 0.0482 0.2613 0.1338
 MPO Activity (U/mg protein) 2.20 ± 0.09 1.90 ± 0.18 3.77 ± 0.17 2.30 ± 0.17 <0.0001 <0.0001 0.0013
Kidney
 MDA (nmol/mL) 101.38 ± 7.84 124.92 ± 6.92 183.00 ± 10.77 133.51 ± 9.85 0.0001 0.1820 0.0010
 NO (nmol/mL) 13.89 ± 1.28 11.21 ± 1.81 62.36 ± 5.49 52.59 ± 1.93 <0.0001 0.0594 0.2684
 APOP (ng/mL) 391.90 ± 40.11 421.75 ± 24.02 978.57 ± 100.73 348.73 ± 35.44 <0.0001 <0.0001 <0.0001
 CATALASE (U/L) 12.72 ± 1.20 10.50 ± 1.50 6.70 ± 0.38 11.08 ± 1.04 0.0234 0.3416 0.0075
 MPO Activity (U/mg protein) 1.94 ± 0.28 1.79 ± 0.18 2.80 ± 0.22 1.85 ± 0.09 0.0359 0.0141 0.0646
  1. Values are presented as mean ± SEM. Two way or One way ANOVA with Bonferoni tests were done as post hoc test
  2. APOP advanced protein oxidation product, expressed as nmol/mL equivalent to Chloramine-T
  3. Values are considered significance at p < 0.05