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Table 1 Baseline clinical data in azelnidipine and amlodipine groups

From: Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study)

  Azelnidipine (n = 19) Amlodipine (n = 19) P
Before After Before After  
Gender (male/female) 9/10 ND 8/11 ND  
Age (years) 59 ± 2 ND 63 ± 2 ND n.s.
BMI (kg/m2) 25.8 ± 1.0 ND 27.1 ± 1.0 ND n.s.
Durations of DM (years) 9.2 ± 2.3 ND 11.3 ± 2.2 ND n.s.
Systolic BP (mmHg) 149 ± 2.4 128 ± 2.9 148 ± 2.9 129 ± 3.3 n.s.
Diastolic BP (mmHg) 80 ± 2.4 68 ± 2.3 84 ± 2.3 72 ± 2.1 n.s.
Heart rate (beats/min) 75 ± 2.8 71 ± 2.5 68 ± 2.3 69 ± 3.5 <0.05
HbA1c (NGSP) (%) 6.9 ± 0.2 6.9 ± 0.2 7.2 ± 0.2 7.3 ± 0.3 n.s.
Fasting plasma glucose (mg/dl) 126 ± 6.4 128 ± 12.3 120 ± 4.6 130 ± 7.5 n.s.
Total cholesterol (mg/dl) 200 ± 6.3 196 ± 7.4 207 ± 6.1 196 ± 5.5 n.s.
HDL cholesterol (mg/dl) 57 ± 3.0 55 ± 3.3 55 ± 3.1 55 ± 2.2 n.s.
LDL cholesterol (mg/dl) 117 ± 6.8 113 ± 6.5 122 ± 4.9 113 ± 5.1 n.s.
Triglyceride (mg/dl) 129 ± 13.4 136 ± 18.0 144 ± 11.4 142 ± 13.4 n.s.
Creatinine (mg/dl) 0.69 ± 0.06 0.76 ± 0.04 0.70 ± 0.04 0.69 ± 0.04 n.s.
BUN (mg/dL) 17.3 ± 1.1 17.1 ± 0.9 17.2 ± 0.8 17.9 ± 0.7 n.s.
eGFR (ml/min/1.73 m2) 75.2 ± 3.6 73.2 ± 3.6 76.9 ± 3.2 78.2 ± 3.3 n.s.
Urinary albumin excretion (mg/g.Cr) 274 ± 202 121 ± 69 136 ± 70 202 ± 114 n.s.
Uric acid (mg/dl) 5.7 ± 0.4 5.7 ± 0.3 5.5 ± 0.3 5.5 ± 0.4 n.s.
Na (mEq/l) 141 ± 0.4 141 ± 0.5 141 ± 0.4 140 ± 0.5 n.s.
K (mEq/l) 4.4 ± 0.1 4.5 ± 0.1 4.2 ± 0.1 4.2 ± 0.1 n.s.
Cl (mEq/l) 105 ± 0.4 104 ± 0.5 105 ± 0.5 104 ± 0.4 n.s.
average IMT (mm) 0.817 ± 0.054 0.759 ± 0.034 0.873 ± 0.063 0.814 ± 0.080 n.s.
Max IMT (mm) 1.102 ± 0.101 0.908 ± 0.004 1.203 ± 0.113 1.124 ± 0.143 n.s.
Other medications
 Sulfonylurea (%) 7 (36.8) 7 (36.8)  
 Metformin (%) 6 (31.6) 7 (36.8)  
 Pioglitazone (%) 9 (47.4) 8 (42.1)  
 α-glucosidase inhibitors (%) 4 (21.1) 2 (10.5)  
 Insulin (%) 1 (5.3) 2 (10.5)  
 Fibrate (%) 2 (10.5) 3 (15.8)  
 Statins (%) 8 (42.1) 7 (36.8)  
  1. ns not significant (azelnidipine vs amlodipine at baseline)
  2. p < 0.05 azelnidipine vs amlodipine at baseline