Fig. 1From: Regulation of hepatic TRB3/Akt interaction induced by physical exercise and its effect on the hepatic glucose production in an insulin resistance stateThe increased expression of TRB3, induced by obesity or by the condition of insulin resistance, promotes a decrease in the phosphorylation of Akt and Foxo1, which enables the translocation of Foxo1 from the cytoplasm to the nucleus. Activated in the nucleus, the Foxo1 increases PGC-1α transcription and its association with this protein, starting the gluconeogenic program. As a consequence, there is an increase in the transcription of gluconeogenic enzymes, such as PEPCK and G6Pase in the liver resulting in hepatic glucose productionBack to article page