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Patients aged ≥35 years
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Use of NPH or regular insulin, pioglitazone, GLP-1 receptor agonist, DPP-4 inhibitor or acarbose
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History of DM and mild hypertension (blood pressure <160/100 mmHg) no longer than 15 years
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Intolerance to metformin
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Body mass index <35 kg/m2
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Use of three or more anti-hypertensive drugs, which characterizes resistant hypertension
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Glycated hemoglobin (HbA1c) between 7.0 and 10.5 %
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Smoking within the previous 6 months
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Pregnancy or breastfeeding
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Creatinine clearance <45 mL/min (MDRD)
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Serum alanine aminotransferase or aspartate aminotransferase level of more than three times the upper limit of the normal range
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Subjects with ischemic heart disease, cerebrovascular disease, other atherosclerotic disease, cancer, or heart failure in functional classes II, III and IV
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Treadmill stress test with typical chest pain or with ST segment depression ≥1 mm, or with a horizontal or descending trace on the electrocardiogram for a duration of 0.08 s after the J point
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Presence of coronary heart disease diagnosed by treadmill stress test, myocardial scintigraphy or coronary angiography
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Inability to give informed consent
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