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Table 3 Discrimination and calibration statistics for diabetes risk model performance in subgroups of participants by gender, age and body mass index (BMI)

From: Independent external validation and comparison of prevalent diabetes risk prediction models in a mixed-ancestry population of South Africa

Models   Male Female Age < 60 years Age ≥ 60 years BMI < 25 kg/m2 BMI ≥ 25 kg/m2
Cambridge Diabetes Risk Score [17] E/O (95 % CI) 2.30 (1.21−3.37) 1.71 (1.00−1.41) 1.57 (0.71−2.44) 2.10 (1.51−2.69) 1.08 (0.55−1.61) 1.96 (1.30−2.63)
Brier score 0.195 0.192 0.151 0.282 0.102 0.230
Yates slope 0.373 0.384 0.368 0.384 0.450 0.368
C-statistic (95 % CI) 0.67 (0.56−0.78) 0.67 (0.62−0.73) 0.66 (0.60−0.72) 0.65 (0.56−0.73) 0.69 (0.58−0.79) 0.64 (0.59−0.70)
Kuwaiti Risk Score [18] E/O (95 % CI) 0.73 (0.40−1.06) 0.72 (0.34−1.10) 0.73 (0.37−1.10) 0.71 (0.32−1.11) 0.33 (0.20−0.46) 0.81 (0.43−1.19)
Brier score 0.112 0.149 0.121 0.186 0.097 0.159
Yates slope 0.588 0.468 0.476 0.449 0.890 0.468
C-statistic (95 % CI) 0.70 (0.58−0.82) 0.67 (0.61−0.72) 0.67 (0.61−0.74) 0.65 (0.57−0.73) 0.61 (0.51−0.72) 0.66 (0.60−0.71)
Omani Diabetes Risk Score [19] E/O (95 % CI) 1.33 (0.45−2.20) 1.32 (0.65−2.00) 1.26 (0.53−1.99) 1.40 (0.60−2.20) 1.16 (0.41−1.92) 1.36 (0.71−2.01)
Brier score 0.137 0.173 0.140 0.221 0.096 0.194
Yates slope 0.347 0.399 0.393 0.296 0.620 0.304
C-statistic (95 % CI) 0.62 (0.49−0.74) 0.66 (0.61−0.71) 0.66 (0.60−0.71) 0.60 (0.52−0.68) 0.71 (0.61−0.82) 0.61 (0.56−0.67)
Rotterdam Predictive Model 1 [20] E/O (95 % CI) 0.84 (−0.38−2.06) 0.48 (0.45−0.93) 0.52 (0.44−0.96) 0.49 (0.39−0.88) 0.72 (0.34−1.06) 0.51 (0.45−0.96)
Brier score 0.117 0.155 0.125 0.199 0.096 0.168
Yates slope 0.913 1.154 1.135 0.838 0.791 0.886
C-statistic (95 % CI) 0.62 (0.49−0.75) 0.66 (0.60−0.72) 0.62 (0.55−0.69) 0.61 (0.52−0.69) 0.61 (0.50−0.72) 0.63 (0.57−0.69)
Simplified Finnish Diabetes Risk score [21] E/O (95 % CI) 0.22 (0.09−0.35) 0.32 (0.18−0.45) 0.34 (0.18−0.50) 0.26 (0.14−0.37) 0.11 (0.06−0.15) 0.34 (0.21−0.48)
Brier score 0.128 0.162 0.128 0.213 0.103 0.176
Yates slope 0.538 0.591 0.487 0.608 1.345 0.562
C-statistic (95 % CI) 0.70 (0.59−0.81) 0.66 (0.60−0.71) 0.64 (0.58−0.71) 0.67 (0.60−0.75) 0.77 (0.69−0.86) 0.62 (0.57−0.68)