Figure 4

Acrophase map of late-treated and early-treated diabetic rats. Diabetic animals received late treatments (top row) or early treatments (bottom row) with insulin (A, D), melatonin (B, E) or a combination of both hormones (C, F). To generate the map, acrophases resulting from day-to-day analyses (averaged in 1 day bins) that showed 24 h oscillations were plotted according to the indicated ZT to generate the daily pattern vertically (mean ± SEM). Arrows indicate the days of STZ induction, treatments and their interruption.