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Table 1 Clinical, anthropometrics, laboratory and polymorphism data of the studied group

From: ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction

Variable Normoweight (51) Overweight (53) Obese (145) P-value
Age, years 46.6. ± 8.3 47.9 ± 6.9 48.7 ± 9.2 0.323
Ethnics [White], % 78.4 (40) 69.8 (37) 71.0(103) 0.539
Woman, % 92.2 (47) 79.2 (42) 75.2 (109) 0.035
Menopause,% 10.6 (5) 26.2 (11) 33.9 (37) 0.011
Hypertension, % 13.7 (7) 28.3 (15) 45.5 (66) <0.001
Type 2 diabetes, % 33.3 (17) 41.5 (22) 55.7 (99) <0.001
Family history of CAD 11.7 (6) 20.8 (11) 17.9 (26) 0.455
Tobacco smoking,% 17.6 (9) 23.2 (10) 13.1 (19) 0.527
Alcohol consumption, % 2.0 (1) 3.8 (2) 3.4 (5) 0.845
Physical exercise practice,% 50.9 (26) 50.9 (27) 29.6 (43) 0.003
Body mass index, kg/m2 22.6 ± 1.7a 27.4 ± 1.4b 35.1 ± 4.2c <0.001
Waist circumference, cm 73.9 ± 8.7a 86.8 ± 9.4b 104.1 ± 11.0c <0.001
Waist- hip ratio 0.78 ± 0.07a 0.84 ± 0.08b 0.90 ± 0.10 c <0.001
Body fat, % 30.9 ± 4.7a 33.9 ± 6.4b 38.5 ± 5.0c <0.001
BMR, kcal 1272 ± 240a 1501 ± 295b 1742 ± 280c <0.001
Leptin, ng/mL 13.6 ± 8.1a 15.7 ± 12.0a,b 22.9 ± 19.2b 0.012
sLEPR, ng/mL 23.8 ± 12.4a 19.1 ± 13.5a,b 20.0 ± 24.0b 0.011
Adiponectin, μg/mL 24.6 ± 23.2 17.7 ± 23.0 27.2 ± 26.4 0.070
Glucose, mg/dL 92 ± 9a 102 ± 26a,b 106 ± 29b <0.001
HbA1c, % 5.5 ± 0.4a 6.0 ± 1.3a,b 6.0 ± 1.4b 0.005
Insulin, mU/L 6.6 ± 4.3a 9.7 ± 6.1b 21.3 ± 12.2b <0.001
HOMA-β 23.0 ± 18.2a 33.3 ± 24.5b 68.7 ± 37.2b <0.001
HOMA-IR 1.5 ± 1.0a 2.4 ± 1.5b 5.9 ± 4.8b <0.001
Total cholesterol, mg/dL 194 ± 36 203 ± 37 209 ± 40 0.077
HDL ccholesterol, mg/dL 65 ± 19a 55 ± 17b 51 ± 12b <0.001
LDL cholesterol, mg/dL 113 ± 32a 125 ± 32a,b 128 ± 32b 0.016
VLDL cholesterol, mg/dL 16 ± 8a 23 ± 10b 30 ± 18c <0.001
Triglycerids, mg/dL 79 ± 38a 114 ± 53b 150 ± 88c <0.001
Apolipoprotein AI, mg/dL 160 ± 40a 152 ± 36a,b 146 ± 31b 0.009
Apolipoprotein B, mg/dL 89 ± 28a 109 ± 38b 101 ± 28b 0.004
Fibrinogen, mg/dL 341 (304–374)a 350 (319–409)a,b 374 (328–446)b <0.001
PAI-1, ng/mL 62.5 (44.7-76.1)a 63.6 (51.0-95.4)a 96.1(60.0-150.6)b <0.001
IL-6, pg/mL 0.08 (0.07-0.09)a 0.09 (0.08-0.55)a,b 0.56 (0.28-1.6)c <0.001
IL-1β, pg/dL 5.0 (4.0-5.6)a 5.9 (4.0-6.1)a,b 18.0 (15.0-51.5)c <0.001
hsCRP, mg/L 0.14 (0.05-0.58)a 0.49 (0.08-1.17)a,b 1.72 (0.26-5.69)c <0.001
TNFα, pg/mL 0.56 (0.09-1.25)a 0.71 (0.32-2.85)a,b 3.17 (1.45-6.05)c <0.001
Minor Allele Frequency, %     
ADIPOQ 45 T > G (rs2241766) 19.6 22.6 21.7 0.858
IL6 -174G > C (rs1800795) 26.4 37.7 31.0 0.209
  1. Number of individuals is in parenthesis. Results are shown as mean ± SD or median (interquartile range) and compared by Anova (Multiple comparisons by Holm-Sidak method) or Kruskal Wallis (Dunn’s Method). Different letters indicate differences between mean values. Categorical variables were compared by chi-square. BMR: basal metabolic rate; CAD: coronary artery disease; HDL: high-density lipoprotein; hsCRP: high sensitive C reactive protein; LDL: low-density lipoprotein; PAI-1: plasminogen activator inhibitor-1; IL-6: interleukin 6; IL-1β: interleukin 1beta; sLEPR: soluble leptin receptor; TNFα: tumor necrosis factor alpha; VLDL: very low-density lipoprotein.
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