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Table 1 Baseline clinical characteristics of subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM)

From: Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance

Factor NGT T2DM
Male Female P Male Female P
N 21 29   23 27  
Age (years) 53.00 (46.50,57.50) 55.00 (49.50,58.00) 0.903 51.82 ± 6.91 51.65 ± 4.66 0.925
Height (cm) 165.76 ± 8.29 154.81 ± 4.13 <0.001* 165.91 ± 5.21 156.06 ± 5.46 <0.001*
Weight (kg) 69.67 ± 7.36 57.36 ± 5.77 <0.001* 70.65 ± 5.88 58.37 ± 7.71 <0.001*
BMI (kg/m2) 25.33 ± 1.56 23.81 ± 2.17 0.009* 25.65 (24.92,26.18) 23.92 (22.76,25.21) 0.003*
Waist (cm) 85.95 ± 4.92 79.91 ± 9.26 0.005* 87.59 ± 4.51 82.79 ± 8.60 0.017*
Hip (cm) 92.14 ± 3.48 89.30 ± 4.40 0.019* 92.80 ± 3.51 89.77 ± 6.51 0.046*
WHR 0.9 3(0.89, 0.98) 0.90 (0.81, 0.94) 0.038* 0.94 ± 0.05 0.92 ± 0.09 0.339
SBP (mmHg) 124.00 (110.00, 134.00) 120.00 (110.00, 130.00) 1.00 130.00 (124.00, 150.00) 140.00 (120.00, 141.00) 0.755
DBP (mmHg) 80.00 (70.00, 90.00) 80.00 (73.00, 85.50) 0.688 90.00 (77.50, 100.00) 83.00 (74.50, 90.00) 0.559
Body fat (kg) 17.48 ± 3.81 19 ± 4.98 0.256 22.49 ± 4.16 20.21 ± 4.52 0.088
BFR (%) 29.05 ± 6.38 30.93 ± 6.71 0.331 32.68 ± 4.56 31.90 ± 5.11 0.596
Muscle mass (kg) 23.74 ± 4.83 23.34 ± 5.25 0.788 25.78 ± 5.49 23.61 ± 3.84 0.140
BUN (mM) 4.76 ± 0.90 5.08 ± 1.77 0.450 4.86 ± 1.00 4.72 ± 1.04 0.627
Cr (uM) 70.10 ± 9.56 54.97 ± 8.75 <0.001* 65.00 ± 11.65 50.70 ± 12.06 <0.001*
UA (uM) 336.24 ± 81.71 223.62 ± 66.61 <0.001* 329.30 ± 78.76 269.67 ± 67.13 0.006*
eGFR (rml/min/1.73 m2) 100.86 ± 11.27 102.74 ± 9.04 0.516 107.63 ± 10.29 109.81 ± 14.63 0.551
TC (mM) 5.10 ± 0.85 5.32 ± 1.27 0.484 4.90 (1.18, 3.31) 5.67 (5.45, 5.90) 0.041*
TG (mM) 1.77 ± 1.04 1.08 ± 0.52 0.009* 1.75 (1.16, 3.33) 1.22 (0.96, 1.89) 0.298
HDL (mM) 1.23 ± 0.24 1.37 ± 0.25 0.054 1.24 ± 0.22 1.48 ± 0.54 0.040*
LDL (mM) 2.94 ± 0.60 3.15 ± 0.95 0.387 2.93 ± 0.82 3.24 ± 0.97 0.233
FFA (mM) 0.38 ± 0.19 0.40 ± 0.16 0.643 0.54 ± 0.27 0.82 ± 1.04 0.234
FPG (mM) 5.40 ± 0.42 5.13 ± 0.42 0.027* 7.47(6.40,8.80) 6.80(6.15,9.43) 0.477
2 h-PG (mM) 5.85 ± 1.32 6.33 ± 3.26 0.118 14.65(12.15,17.73) 14.15(12.15,19.73) 0.586
HbA1C (%) 5.55 (5.30, 5.70) 5.40 (5.20, 5.60) 0.206 6.60 (5.80, 8.20) 6.50 (5.90, 8.38) 0.741
FINS (mU/l) 4.15 (3.21, 6.71) 5.67 (3.82, 6.72) 0.254 8.85 (6.26, 11.53) 9.07 (6.47, 12.13) 0.969
HOMA-IR 1.38 ± 0.75 1.71 ± 0.91 0.182 2.82 (2.04, 3.31) 2.77 (2.27, 5.00) 0.633
HOMA-β (%) 27.67 (19.67, 60.77) 35.70 (25.00, 54.10) 0.331 43.25 (30.03, 62.47) 53.64 (33.12, 81.99) 0.430
Betatrophin (pg/ml) 299.61(146.56,439.65) 242.07(67.68,319.41) 0.033* 498.86 ± 239.79 334.59 ± 216.42 0.014*
Irisin (ng/ml) 244.38 (214.18, 305.92) 243.57 (193.49, 347.25) 0.687 249.53 (202.21, 455.08) 241.81 (205.82, 278.94) 0.808
  1. Data are presented as the mean ± SD or median (interquartile range). *,P<0.05.
  2. BMI: body mass index; WHR: waist-to-hip ratio; SDP: systolic blood pressure; DBP: diastolic blood pressure; BFR: body fat rate; BUN: blood urea nitrogen; Cr: creatinine; UA: uric acid; eGFR: estimated glomerular filtration rate; TC: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; FFA: free fatty acids; FPG: fasting plasma glucose; 2 h-PG: 2 h plasma glucose; HbA1C: hemoglobin A1C; FINS: fasting insulin HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-β: homeostasis model assessment-β.