Table 2 Incidence rates and risk of ischemic stroke associated with use of low-dose aspirin among patients with diabetes
Aspirin non-user | Low-dose aspirin user | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Event (N) | Person-years | Crude incidence rate (/1,000 person-years) | Event (N) | Person-years | Crude incidence rate (/1,000person-years) | Crude hazard ratio (95%CI) | Adjusted hazard ratio * (95% CI) | ||
Whole matched cohort | 158 | 48,725 | 3.2 | 340 | 44,592 | 5.4 | 1.64 (1.32-1.98) | 1.73 (1.41-2.12) | |
Gender | Male | 81 | 27,565 | 2.9 | 137 | 25,224 | 5.4 | 1.86 (1.56-2.23) | 1.93 (1.46-2.55) |
Female | 77 | 21,160 | 3.6 | 103 | 19,368 | 5.3 | 1.45 (1.08-1.95) | 1.52 (1.13-2.15) | |
Age | 40-69 | 85 | 39,758 | 2.1 | 136 | 37,060 | 3.7 | 1.69 (1.28-2.22) | 1.81 (1.37-2.38) |
70-99 | 73 | 8,967 | 8.1 | 104 | 7,867 | 11.6 | 1.65 (1.23-2.23) | 1.72 (1.27-2.33) | |
Type of diabetes | Type 1 only | 14 | 3,078 | 4.5 | 19 | 2,287 | 8.3 | 1.74 (0.87-3.47) | 1.82 (0.90-3.68) |
Type 2 and others | 144 | 45,647 | 3.2 | 221 | 42,305 | 5.2 | 1.61 (1.31-1.99) | 1.73 (1.40-2.14) | |
Diabetes with essential hypertension | Yes | 97 | 24,791 | 3.9 | 135 | 21,306 | 6.3 | 1.59 (1.23-2.07) | 1.69 (1.30-2.20) |
No | 61 | 23,934 | 2.5 | 105 | 23,286 | 4.5 | 1.70 (1.24-2.33) | 1.81 (1.32-2.51) | |
Diabetes with dyslipidemia | Yes | 39 | 13,501 | 2.9 | 48 | 11,255 | 4.3 | 1.44 (0.94-2.14) | 1.68 (1.09-2.57) |
No | 119 | 35,224 | 3.4 | 192 | 33,337 | 5.8 | 1.65 (1.31-2.08) | 1.75 (1.39-2.21) | |