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Table 2 Incidence rates and risk of ischemic stroke associated with use of low-dose aspirin among patients with diabetes

From: Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study

   Aspirin non-user Low-dose aspirin user  
   Event (N) Person-years Crude incidence rate (/1,000 person-years) Event (N) Person-years Crude incidence rate (/1,000person-years) Crude hazard ratio (95%CI) Adjusted hazard ratio * (95% CI)
Whole matched cohort 158 48,725 3.2 340 44,592 5.4 1.64 (1.32-1.98) 1.73 (1.41-2.12)
Gender Male 81 27,565 2.9 137 25,224 5.4 1.86 (1.56-2.23) 1.93 (1.46-2.55)
  Female 77 21,160 3.6 103 19,368 5.3 1.45 (1.08-1.95) 1.52 (1.13-2.15)
Age 40-69 85 39,758 2.1 136 37,060 3.7 1.69 (1.28-2.22) 1.81 (1.37-2.38)
  70-99 73 8,967 8.1 104 7,867 11.6 1.65 (1.23-2.23) 1.72 (1.27-2.33)
Type of diabetes Type 1 only 14 3,078 4.5 19 2,287 8.3 1.74 (0.87-3.47) 1.82 (0.90-3.68)
  Type 2 and others 144 45,647 3.2 221 42,305 5.2 1.61 (1.31-1.99) 1.73 (1.40-2.14)
Diabetes with essential hypertension Yes 97 24,791 3.9 135 21,306 6.3 1.59 (1.23-2.07) 1.69 (1.30-2.20)
No 61 23,934 2.5 105 23,286 4.5 1.70 (1.24-2.33) 1.81 (1.32-2.51)
Diabetes with dyslipidemia Yes 39 13,501 2.9 48 11,255 4.3 1.44 (0.94-2.14) 1.68 (1.09-2.57)
No 119 35,224 3.4 192 33,337 5.8 1.65 (1.31-2.08) 1.75 (1.39-2.21)
  1. CI: confidence interval.
  2. *Adjusted Hazard Ratio calculated using Cox proportional hazard model adjusting for insurance type, anti-diabetic medications at baseline, use of statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta blockers, calcium channel blockers and thiazide diuretics during follow-up.