| | |
Aspirin non-user
|
Low-dose aspirin user
| |
|---|
| | |
Event (N)
|
Person-years
|
Crude incidence rate (/1,000 person-years)
|
Event (N)
|
Person-years
|
Crude incidence rate (/1,000person-years)
|
Crude hazard ratio (95%CI)
|
Adjusted hazard ratio
*
(95% CI)
|
|---|
|
Whole matched cohort
|
158
|
48,725
|
3.2
|
340
|
44,592
|
5.4
|
1.64 (1.32-1.98)
|
1.73 (1.41-2.12)
|
|
Gender
|
Male
|
81
|
27,565
|
2.9
|
137
|
25,224
|
5.4
|
1.86 (1.56-2.23)
|
1.93 (1.46-2.55)
|
| |
Female
|
77
|
21,160
|
3.6
|
103
|
19,368
|
5.3
|
1.45 (1.08-1.95)
|
1.52 (1.13-2.15)
|
|
Age
|
40-69
|
85
|
39,758
|
2.1
|
136
|
37,060
|
3.7
|
1.69 (1.28-2.22)
|
1.81 (1.37-2.38)
|
| |
70-99
|
73
|
8,967
|
8.1
|
104
|
7,867
|
11.6
|
1.65 (1.23-2.23)
|
1.72 (1.27-2.33)
|
|
Type of diabetes
|
Type 1 only
|
14
|
3,078
|
4.5
|
19
|
2,287
|
8.3
|
1.74 (0.87-3.47)
|
1.82 (0.90-3.68)
|
| |
Type 2 and others
|
144
|
45,647
|
3.2
|
221
|
42,305
|
5.2
|
1.61 (1.31-1.99)
|
1.73 (1.40-2.14)
|
|
Diabetes with essential hypertension
|
Yes
|
97
|
24,791
|
3.9
|
135
|
21,306
|
6.3
|
1.59 (1.23-2.07)
|
1.69 (1.30-2.20)
|
|
No
|
61
|
23,934
|
2.5
|
105
|
23,286
|
4.5
|
1.70 (1.24-2.33)
|
1.81 (1.32-2.51)
|
|
Diabetes with dyslipidemia
|
Yes
|
39
|
13,501
|
2.9
|
48
|
11,255
|
4.3
|
1.44 (0.94-2.14)
|
1.68 (1.09-2.57)
|
|
No
|
119
|
35,224
|
3.4
|
192
|
33,337
|
5.8
|
1.65 (1.31-2.08)
|
1.75 (1.39-2.21)
|
- CI: confidence interval.
-
*Adjusted Hazard Ratio calculated using Cox proportional hazard model adjusting for insurance type, anti-diabetic medications at baseline, use of statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta blockers, calcium channel blockers and thiazide diuretics during follow-up.
