Skip to main content


Evaluation on physiological biomarkers pre and during gestational period in immunosuppressed Wistar rats with mycophenolate sodium

Article metrics

  • 362 Accesses


The use of medication during pregnancy should be taken with caution, especially because of its implications for maternal and fetal health. The mycophenolate sodium (MFS) is used to avoid possible rejection of transplanted tissues and organs by inhibiting T and B lymphocyte proliferation.


To evaluate the effects of maternal immunosuppression by MFS on physiological parameters in rats.

Materials and methods

The rats were divided into three groups: rats treated with water (CONT=10) rats orally treated with MFS (20mg/Kg) daily for 15 days until a positive diagnosis of pregnancy (MICO-1=10) and rats orally treated with MFS (20mg/Kg) daily for 15 days prior to and during 21 days of pregnancy (MICO-2=10). It was weekly evaluated body weight, blood glucose, and water and food intake (before and during pregnancy). Statistical significance was p <0.05.


In the pre-pregnancy period, although there were no changes in body weight values, the continuous treatment with MFS decreased food and water consumption and also increased blood glucose (MICO-2). During pregnancy period, these rats presented a reduction of the body weight, maintaining a mild hyperglycemia level (about 170 mg/dL)


The continued use of MFS during pregnancy can be considered toxic, damaging the maternal health, lead to mild hyperglycemia state plus some toxic data (low food and water intake). This study shows that MFS use is not recommended during pregnancy freely and should be replaced by another immunosuppressant.

Author information

Correspondence to Amanda Lima Deluque.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark


  • Blood Glucose
  • Water Intake
  • Water Consumption
  • Maternal Health
  • Lymphocyte Proliferation