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Glycemic control affecting the autonomic modulation in type 2 diabetes


Diabetes Mellitus (DM) is a chronic disease with high morbidity and mortality and one of the most important risk factors for developing cardiovascular disease. DM is associated with cardiac autonomic dysfunction.


To evaluate if the glycemic control affects cardiac autonomic modulation in individuals with type 2 diabetes.

Materials and methods

We evaluated 49 patients (51.2±7.7 yrs.) with a confirmed diagnosis of diabetes. The subjects were randomized in two groups according to glycated hemoglobin-HbA1c: HbA1c < 7% and HbA1c >7%. The fasting plasma glucose and HbA1c were performed in a specialized laboratory and HR and iRR were recorded for 10 min in the supine position. Statistical analysis included Shapiro-Wilk Test, Mann Whitney Test and Spearman Correlation.


Diabetics with HbA1c>7 presented lower values of all HRV indices compared to diabetics with HbA1c<7 (mean iRR=844.25±117.64 vs 928.47±67.83 ms; STDRR=21.13±12.85 vs 34.92±19.51 ms; RR Tri=5.57±3.07 vs 9.02±5.12; TINN=107.82±65.72 vs 149±50.32, SD2=37.70±19.11 vs 61.94±25.06 ms, except for mean HR (72.45±9.55 vs 65.12±4.91 bpm) where was higher in HbA1c>7 group. HbA1c was negatively correlated with mean iRR (r=-0.28); STDRR(r=-0.33); RRTri (r=-0.35), SD2(r=-0.39) and positively with mean HR (r=0.28). Whereas fasting plasma glucose was negatively correlated with SD2 (r=-0.42); STDRR(r=-0.36), RRTri (r=-0.36) and TINN (r=0.33).


These findings suggest attenuated cardiac autonomic response in diabetics type 2 with poor metabolic control.

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Correspondence to Daniela Bassi.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Bassi, D., Arakelian, V.M., Mendes, R.G. et al. Glycemic control affecting the autonomic modulation in type 2 diabetes. Diabetol Metab Syndr 7 (Suppl 1), A3 (2015).

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