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  • Meeting abstract
  • Open Access

Metabolic syndrome, diabetes and inadequate lifestyle in first-degree relatives of acute myocardial infarction survivors younger than 45 yrs. old

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Diabetology & Metabolic Syndrome20157 (Suppl 1) :A161

  • Published:


  • Cholesterol
  • Blood Glucose
  • Metabolic Syndrome
  • Blood Glucose Level
  • Acute Myocardial Infarction


Acute Myocardial infarction (AMI) before the age of 45 is unusual and is associated with a familial component.This study evaluated cardiovascular risk factors in a cross-sectional study of first-degree relatives of Brazilian patients with premature MI.

Materials and methods

A total of 166 first-degree relatives (FDR) of 103 patients with MI age <45 yrs. were matched for sex and age with a group of 111 individuals with no family history of cardiovascular disease (control group). Familial hypercholesterolemia was excluded. Patients were evaluated for the presence of metabolic syndrome, its components, and lifestyle (smoking, alcohol consumption, and sedentarism). Laboratory analysis included fasting blood glucose, plasma lipids and thyrotropin (TSH).


The prevalences of smoking (29.5 vs. 6.3%, p<0.001), prediabetes (40.4 vs. 27, p<0.001), diabetes (19.9 vs. 1.8%, p<0.001), metabolic syndrome (64.7 vs. 36%, p<0.001), and dyslipidaemia (84.2 x 31.2%, p: 0.001) were higher in FDR individuals. Triglycerides (179±71 vs. 140±74mg/dL, p: 0.002), LDL-cholesterol (122±36vs.113±35mg/dL, p: 0.031), non-HDL cholesterol (157±53 vs.141±41mg/dL, p: 0.004), and TSH levels (2.4±1.6 vs. 1.9±1.0, p: 0.002) were also higher, and HDL-cholesterol (39±10 vs. 48±14mg/dL, p<0.001) lower in FDR. No significant differences were observed between groups for body mass index, abdominal obesity, hypertension, total cholesterol, and fasting blood glucose levels.


FDR of patients with AMI < age of 45 yrs. old without familial hypercolesterolemia present elevated prevalence of the metabolic syndrome and its components, as well as an inadequate lifestyle.

Authors’ Affiliations

Faculdade de Medicina da universidade Federal do Ceará, Fortaleza, Brazil


© da Costa Gurgel Castelo et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.